| Literature DB >> 14872541 |
Jian Li1, Craig R Rayner, Shirley Dixson, Roger L Nation.
Abstract
A simple HPLC method was developed and validated for quantification of linezolid in Brain Heart Infusion (BHI) broth. Eperezolid was employed as internal standard and the sample pre-treatment procedure was simple. Calibration standards ranged from 0.05 to 16 mg/L. Accuracy was within 7.8% and reproducibility (RSD) was less than 8.3%. Recovery was approximately 100% at all concentrations examined. Linezolid was stable in the autosampler insert for at least 24 h at ambient temperature and in BHI for 72 h at 37 degrees C. This assay is rapid and ideal for analysis of a large number of samples. Copyright 2003 John Wiley & Sons, Ltd.Entities:
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Year: 2004 PMID： 14872541 DOI： 10.1002/bmc.283
Source DB: PubMed Journal: Biomed Chromatogr ISSN： 0269-3879 Impact factor: 1.902