OBJECTIVE: In the K/BxN mouse model, autoantibodies against glucose-6-phosphate isomerase (GPI) cause arthritis. The relevance of this model for human disease remains a subject of controversy. We set out to determine whether GPI autoantibodies occur in patients with rheumatoid arthritis (RA) and, if so, at what stage of the RA. METHODS: Using an enzyme-linked immunosorbent assay, serum from 131 RA patients and 28 healthy controls was tested for autoantibodies against recombinant human GPI. Patients were grouped according to disease duration and presence of rheumatoid nodules, rheumatoid vasculitis, and Felty's syndrome, which are extraarticular complications of RA. RESULTS: Elevated levels of autoantibodies against GPI were present in 5% of patients with uncomplicated RA and 4% of controls. In RA complicated by extraarticular manifestations, anti-GPI antibodies were observed in 18% of patients with rheumatoid nodules, 45% of patients with rheumatoid vasculitis, and 92% of patients with Felty's syndrome. CONCLUSION: In patients with RA, autoantibodies to GPI are associated with the occurrence of extraarticular complications.
OBJECTIVE: In the K/BxN mouse model, autoantibodies against glucose-6-phosphate isomerase (GPI) cause arthritis. The relevance of this model for human disease remains a subject of controversy. We set out to determine whether GPI autoantibodies occur in patients with rheumatoid arthritis (RA) and, if so, at what stage of the RA. METHODS: Using an enzyme-linked immunosorbent assay, serum from 131 RApatients and 28 healthy controls was tested for autoantibodies against recombinant humanGPI. Patients were grouped according to disease duration and presence of rheumatoid nodules, rheumatoid vasculitis, and Felty's syndrome, which are extraarticular complications of RA. RESULTS: Elevated levels of autoantibodies against GPI were present in 5% of patients with uncomplicated RA and 4% of controls. In RA complicated by extraarticular manifestations, anti-GPI antibodies were observed in 18% of patients with rheumatoid nodules, 45% of patients with rheumatoid vasculitis, and 92% of patients with Felty's syndrome. CONCLUSION: In patients with RA, autoantibodies to GPI are associated with the occurrence of extraarticular complications.
Authors: N Umeda; I Matsumoto; I Ito; A Kawasaki; Y Tanaka; A Inoue; H Tsuboi; T Suzuki; T Hayashi; S Ito; N Tsuchiya; T Sumida Journal: Clin Exp Immunol Date: 2013-04 Impact factor: 4.330
Authors: Y Tanaka-Watanabe; I Matsumoto; K Iwanami; A Inoue; D Goto; S Ito; A Tsutsumi; T Sumida Journal: Clin Exp Immunol Date: 2008-11-20 Impact factor: 4.330
Authors: Paul A Monach; Wolfgang Hueber; Benedikt Kessler; Beren H Tomooka; Maya BenBarak; Barry P Simmons; John Wright; Thomas S Thornhill; Marc Monestier; Hidde Ploegh; William H Robinson; Diane Mathis; Christophe Benoist Journal: Proc Natl Acad Sci U S A Date: 2009-08-31 Impact factor: 11.205
Authors: Paul A Monach; Admar Verschoor; Jonathan P Jacobs; Michael C Carroll; Amy J Wagers; Christophe Benoist; Diane Mathis Journal: Arthritis Rheum Date: 2007-09