PURPOSE: To assess the use of time-resolved parallel 3D MRI for a quantitative analysis of pulmonary perfusion in patients with cardiopulmonary disease. MATERIALS AND METHODS: Eight patients with pulmonary embolism or pulmonary hypertension were examined with a time-resolved 3D gradient echo pulse sequence with parallel imaging techniques (FLASH 3D, TE/TR: 0.8/1.9 ms; flip angle: 40 degrees; GRAPPA). A quantitative perfusion analysis based on indicator dilution theory was performed using a dedicated software. RESULTS: Patients with pulmonary embolism or chronic thromboembolic pulmonary hypertension revealed characteristic wedge-shaped perfusion defects at perfusion MRI. They were characterized by a decreased pulmonary blood flow (PBF) and pulmonary blood volume (PBV) and increased mean transit time (MTT). Patients with primary pulmonary hypertension or Eisenmenger syndrome showed a more homogeneous perfusion pattern. The mean MTT of all patients was 3.3 - 4.7 s. The mean PBF and PBV showed a broader interindividual variation (PBF: 104 - 322 ml/100 ml/min; PBV: 8 - 21 ml/100 ml). CONCLUSION: Time-resolved parallel 3D MRI allows at least a semi-quantitative assessment of lung perfusion. Future studies will have to assess the clinical value of this quantitative information for the diagnosis and management of cardiopulmonary disease.
PURPOSE: To assess the use of time-resolved parallel 3D MRI for a quantitative analysis of pulmonary perfusion in patients with cardiopulmonary disease. MATERIALS AND METHODS: Eight patients with pulmonary embolism or pulmonary hypertension were examined with a time-resolved 3D gradient echo pulse sequence with parallel imaging techniques (FLASH 3D, TE/TR: 0.8/1.9 ms; flip angle: 40 degrees; GRAPPA). A quantitative perfusion analysis based on indicator dilution theory was performed using a dedicated software. RESULTS:Patients with pulmonary embolism or chronic thromboembolic pulmonary hypertension revealed characteristic wedge-shaped perfusion defects at perfusion MRI. They were characterized by a decreased pulmonary blood flow (PBF) and pulmonary blood volume (PBV) and increased mean transit time (MTT). Patients with primary pulmonary hypertension or Eisenmenger syndrome showed a more homogeneous perfusion pattern. The mean MTT of all patients was 3.3 - 4.7 s. The mean PBF and PBV showed a broader interindividual variation (PBF: 104 - 322 ml/100 ml/min; PBV: 8 - 21 ml/100 ml). CONCLUSION: Time-resolved parallel 3D MRI allows at least a semi-quantitative assessment of lung perfusion. Future studies will have to assess the clinical value of this quantitative information for the diagnosis and management of cardiopulmonary disease.
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Authors: Sebastian Ley; Christian Fink; Julia Zaporozhan; Mathias M Borst; F Joachim Meyer; Michael Puderbach; Monika Eichinger; Christian Plathow; Ekkehard Grünig; Karl-Friedrich Kreitner; Hans-Ulrich Kauczor Journal: Eur Radiol Date: 2005-07-22 Impact factor: 5.315