Literature DB >> 14872046

Axonal injury, a neglected cause of CNS damage in bacterial meningitis.

Roland Nau1, Joachim Gerber, Stephanie Bunkowski, Wolfgang Brück.   

Abstract

The contribution of axonal injury to CNS damage in bacterial meningitis was studied by histology and immunohistochemistry for amyloid-beta precursor protein in humans and experimental rabbits. Axonal injury in the white matter caused predominantly but not exclusively by ischemia was detected in all autopsy cases (n = 5) and in 11 of 15 brains of rabbits 18 to 24 hours after intracisternal infection with Streptococcus pneumoniae. This suggests a substantial contribution of axonal pathology to neurologic sequelae after bacterial meningitis.

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Year:  2004        PMID： 14872046     DOI： 10.1212/01.wnl.0000106826.82670.30

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

1.  Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections.

Authors:  Jan Jessen Krut; Henrik Zetterberg; Kaj Blennow; Paola Cinque; Lars Hagberg; Richard W Price; Marie Studahl; Magnus Gisslén
Journal:  J Neurol       Date:  2012-10-09       Impact factor: 4.849

Review 2.  Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration.

Authors:  Juan A Orellana; Pablo J Sáez; Kenji F Shoji; Kurt A Schalper; Nicolás Palacios-Prado; Victoria Velarde; Christian Giaume; Michael V L Bennett; Juan C Sáez
Journal:  Antioxid Redox Signal       Date:  2009-02       Impact factor: 8.401

3.  Focal parenchymal lesions in community-acquired bacterial meningitis in adults: a clinico-radiological study.

Authors:  Juri Katchanov; Eberhard Siebert; Matthias Endres; Randolf Klingebiel
Journal:  Neuroradiology       Date:  2009-07-18       Impact factor: 2.804

4.  Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis.

Authors:  David Liebetanz; Joachim Gerber; Christina Schiffner; Sandra Schütze; Florian Klinker; Hubertus Jarry; Roland Nau; Simone C Tauber
Journal:  J Neuroinflammation       Date:  2012-07-10       Impact factor: 8.322

5.  Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.

Authors:  Cornelia Demel; Tobias Hoegen; Armin Giese; Barbara Angele; Hans-Walter Pfister; Uwe Koedel; Matthias Klein
Journal:  J Neuroinflammation       Date:  2011-01-24       Impact factor: 8.322

6.  Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.

Authors:  Sandra Redlich; Sandra Ribes; Sandra Schütze; Roland Nau
Journal:  J Neuroinflammation       Date:  2014-06-14       Impact factor: 8.322

7.  Role of neural barriers in the pathogenesis and outcome of Streptococcus pneumoniae meningitis.

Authors:  Ofer Prager; Alon Friedman; Yaffa Mizrachi Nebenzahl
Journal:  Exp Ther Med       Date:  2017-01-24       Impact factor: 2.447

8.  The inflammatory response and neuronal injury in Streptococcus suis meningitis.

Authors:  Jana Seele; Simone C Tauber; Stephanie Bunkowski; Christoph G Baums; Peter Valentin-Weigand; Nicole de Buhr; Andreas Beineke; Asparouh I Iliev; Wolfgang Brück; Roland Nau
Journal:  BMC Infect Dis       Date:  2018-07-03       Impact factor: 3.090

Review 9.  Host-pathogen interactions in bacterial meningitis.

Authors:  Kelly S Doran; Marcus Fulde; Nina Gratz; Brandon J Kim; Roland Nau; Nemani Prasadarao; Alexandra Schubert-Unkmeir; Elaine I Tuomanen; Peter Valentin-Weigand
Journal:  Acta Neuropathol       Date:  2016-01-07       Impact factor: 17.088

10.  Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis.

Authors:  Ngoc Dung Le; Lukas Muri; Denis Grandgirard; Jens Kuhle; David Leppert; Stephen L Leib
Journal:  J Neuroinflammation       Date:  2020-10-07       Impact factor: 8.322
  10 in total

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