Literature DB >> 14870856

Tools for microwave-assisted parallel syntheses and combinatorial chemistry.

Matthias Nüchter1, Bernd Ondruschka.   

Abstract

A protocol for transferring conventional reactions to the microwave field explores the effectiveness of parallel syntheses and combination approaches. Applicability to the reaction systems combiCHEM, multiPREP, MMR8 and HPR is defined. Model reactions have been performed in laboratory equipment. Emphasis is placed on similar reaction conditions in the individual vessels and the repeatability of results. Outcomes include esterifications and multi-center reactions exhibiting a great potential for combinatorial chemistry.

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Year:  2003        PMID： 14870856     DOI： 10.1023/b:modi.0000006916.69862.3d

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  9 in total

1.  Microwave-assisted high-speed chemistry: a new technique in drug discovery.

Authors:  M Larhed; A Hallberg
Journal:  Drug Discov Today       Date:  2001-04-01       Impact factor: 7.851

Review 2.  Drug discovery in the next millennium.

Authors:  E H Ohlstein; R R Ruffolo; J D Elliott
Journal:  Annu Rev Pharmacol Toxicol       Date:  2000       Impact factor: 13.820

3.  AutoChem: automated solution-phase parallel synthesis and purification via HPLC.

Authors:  R A Tommasi; L W Whaley; H R Marepalli
Journal:  J Comb Chem       Date:  2000 Sep-Oct

4.  Methodologies for Generating Solution-Phase Combinatorial Libraries.

Authors:  Haoyun An; P. Dan Cook
Journal:  Chem Rev       Date:  2000-09-15       Impact factor: 60.622

Review 5.  Increasing rates of reaction: microwave-assisted organic synthesis for combinatorial chemistry.

Authors:  Amy Lew; Peter O Krutzik; Matthew E Hart; A Richard Chamberlin
Journal:  J Comb Chem       Date:  2002 Mar-Apr

6.  The "One-Bead-One-Compound" Combinatorial Library Method.

Authors:  Kit S. Lam; Michal Lebl; Viktor Krchnák
Journal:  Chem Rev       Date:  1997-04-01       Impact factor: 60.622

7.  A combinatorial scaffold approach toward kinase-directed heterocycle libraries.

Authors:  Sheng Ding; Nathanael S Gray; Xu Wu; Qiang Ding; Peter G Schultz
Journal:  J Am Chem Soc       Date:  2002-02-27       Impact factor: 15.419

Review 8.  Microwave-accelerated homogeneous catalysis in organic chemistry.

Authors:  Mats Larhed; Christina Moberg; Anders Hallberg
Journal:  Acc Chem Res       Date:  2002-09       Impact factor: 22.384

9.  Microwave parallel library generation: comparison of a conventional- and microwave-generated substituted 4(5)-sulfanyl-1H-imidazole library.

Authors:  Claire M Coleman; J M D MacElroy; John F Gallagher; Donal F O'Shea
Journal:  J Comb Chem       Date:  2002 Jan-Feb
  9 in total
  2 in total

1.  Parallel microwave chemistry in silicon carbide reactor platforms: an in-depth investigation into heating characteristics.

Authors:  Markus Damm; C Oliver Kappe
Journal:  Mol Divers       Date:  2009-06-23       Impact factor: 2.943

2.  One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues.

Authors:  Jessica Bais; Fabio Benedetti; Federico Berti; Iole Cerminara; Sara Drioli; Maria Funicello; Giorgia Regini; Mattia Vidali; Fulvia Felluga
Journal:  Molecules       Date:  2020-09-10       Impact factor: 4.411
  2 in total

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