Literature DB >> 14870775

Immunohistochemical markers of thyroid tumors: significance and diagnostic applications.

Juan Rosai1.   

Abstract

Immunohistochemical markers of thyroid tumors can be divided into two major categories: those related to the cell types and those related to the type of pathology. The most important markers in the first category are thyroglobulin and TTF-1 for follicular cells, and calcitonin, CEA, and chromogranin for C cells. Markers in the second category are primarily directed at papillary carcinoma and include cytokeratin 19, high-molecular weight keratin (identifiable with antibody 34betaE12), S-100 protein, HBME-1, galectin 3, and p27kip1. At the practical level, cell type-related markers are much more useful than disease-related markers. Markers said to be of prognostic value in medullary carcinomas are calcitonin, bcl-2, and N-myc.

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Year:  2003        PMID： 14870775     DOI： 10.1177/030089160308900511

Source DB:  PubMed          Journal:  Tumori        ISSN： 0300-8916


  10 in total

1.  Unique growth pattern in papillary carcinoma of the thyroid gland mimicking adenoid cystic carcinoma.

Authors:  Zubair W Baloch; Jeremy P Segal; Virginia A Livolsi
Journal:  Endocr Pathol       Date:  2011-12       Impact factor: 3.943

2.  ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy.

Authors:  Electron Kebebew; Miao Peng; Emily Reiff; Quan-Yang Duh; Orlo H Clark; Alex McMillan
Journal:  Ann Surg       Date:  2005-09       Impact factor: 12.969

3.  Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue.

Authors:  Lewis M Brown; Steve M Helmke; Stephen W Hunsucker; Romana T Netea-Maier; Simon A Chiang; David E Heinz; Kenneth R Shroyer; Mark W Duncan; Bryan R Haugen
Journal:  Mol Carcinog       Date:  2006-08       Impact factor: 4.784

4.  Emerin expression in well differentiated epithelial lesions of thyroid: implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior.

Authors:  Ipek Coban; Asli Cakir; Tuba Dilay Kokenek Unal; Nuray Bassullu; Vildan Karpuz; Gulen Bulbul Dogusoy; Murat Alper
Journal:  Pathol Oncol Res       Date:  2014-08-14       Impact factor: 3.201

5.  A case of primary thyroid squamous cell cancer: transformation from benign tumour associated with chronic thyroiditis?

Authors:  Tatsuya Kondo; Akiko Matsuyoshi; Hidetake Matsuyoshi; Rieko Goto; Kaoru Ono; Yumi Honda; Ken-Ichi Iyama; Kaku Tsuruzoe; Nobuhiro Miyamura; Eiichi Araki
Journal:  BMJ Case Rep       Date:  2009-04-14

6.  BRAF (V600E) associates with cytoplasmatic localization of p27kip1 and higher cytokeratin 19 expression in papillary thyroid carcinoma.

Authors:  Anna Guerra; Vincenzo Marotta; Maurilio Deandrea; Manuela Motta; Paolo Piero Limone; Alessia Caleo; Pio Zeppa; Silvano Esposito; Franco Fulciniti; Mario Vitale
Journal:  Endocrine       Date:  2012-12-01       Impact factor: 3.633

7.  New prognostic scales LAST-1 and LAST-2: supporting prediction and staging of thyroid cancer.

Authors:  Andrzej J Lachinski; Tomasz Stefaniak; Jarek Kobiela; Saxon Connor; Zbigniew Gruca; Zbigniew Sledzinski
Journal:  World J Surg       Date:  2006-03       Impact factor: 3.352

8.  Diagnostic value of differential expression of CK19, Galectin-3, HBME-1, ERK, RET, and p16 in benign and malignant follicular-derived lesions of the thyroid: an immunohistochemical tissue microarray analysis.

Authors:  J E Barroeta; Z W Baloch; P Lal; T L Pasha; P J Zhang; V A LiVolsi
Journal:  Endocr Pathol       Date:  2006       Impact factor: 4.056

9.  Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells.

Authors:  Marie Gilbert-Sirieix; Joelle Makoukji; Shioko Kimura; Monique Talbot; Bernard Caillou; Charbel Massaad; Liliane Massaad-Massade
Journal:  PLoS One       Date:  2011-07-21       Impact factor: 3.240

10.  Large needle aspiration biopsy and galectin-3 determination in selected thyroid nodules with indeterminate FNA-cytology.

Authors:  A Carpi; A G Naccarato; G Iervasi; A Nicolini; G Bevilacqua; P Viacava; P Collecchi; L Lavra; C Marchetti; S Sciacchitano; A Bartolazzi
Journal:  Br J Cancer       Date:  2006-06-27       Impact factor: 7.640
  10 in total

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