| Literature DB >> 1486568 |
G Rege-Cambrin1, P Scaravaglio, F Carozzi, S Giordano, C Ponzetto, P M Comoglio, G Saglio.
Abstract
MKN 45 is a poorly differentiated gastric carcinoma cell line from which the subclone GTL 16 was obtained. Both lines carry an amplification unit derived from chromosome 7 sequences and containing an activated c-met oncogene. Karyotypic analysis showed that GTL 16 derived from a subclone of MKN 45 after endoreduplication. Several clonal abnormalities are evident in both lines; some are frequently observed in gastrointestinal tumors (loss of 17p and monosomy 18). Other consistent anomalies include 6q-, t(8;10) and t(5;8), and inv(16). A marker chromosome (M1), which was previously shown to contain the c-met amplification unit, is constantly duplicated in all GTL 16 metaphases; in contrast, most unidentified markers are retained in only a single copy in GTL 16 cells. These data are in agreement with the hypothesis that the c-met oncogene activation in these gastric cancer cell lines might be related to a gene dosage effect.Entities:
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Year: 1992 PMID： 1486568 DOI： 10.1016/0165-4608(92)90350-h
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608