Literature DB >> 1485915

Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase.

D K St Clair1, X S Wan, T D Oberley, K E Muse, W H St Clair.   

Abstract

Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation-, but not chemically-induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation.

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Year:  1992        PMID： 1485915     DOI： 10.1002/mc.2940060404

Source DB:  PubMed          Journal:  Mol Carcinog        ISSN： 0899-1987            Impact factor:   4.784


  42 in total

Review 1.  Reactive Oxygen Species: the Dual Role in Physiological and Pathological Conditions of the Human Body.

Authors:  Sanaa K Bardaweel; Mustafa Gul; Muhammad Alzweiri; Aman Ishaqat; Husam A ALSalamat; Rasha M Bashatwah
Journal:  Eurasian J Med       Date:  2018-10

2.  Late ROS accumulation and radiosensitivity in SOD1-overexpressing human glioma cells.

Authors:  Zhen Gao; Ehab H Sarsour; Amanda L Kalen; Ling Li; Maneesh G Kumar; Prabhat C Goswami
Journal:  Free Radic Biol Med       Date:  2008-08-14       Impact factor: 7.376

3.  Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species.

Authors:  Nukhet Aykin-Burns; Benjamin G Slane; Annie T Y Liu; Kjerstin M Owens; Malinda S O'Malley; Brian J Smith; Frederick E Domann; Douglas R Spitz
Journal:  Radiat Res       Date:  2010-11-17       Impact factor: 2.841

Review 4.  ROS in Cancer: The Burning Question.

Authors:  Iok In Christine Chio; David A Tuveson
Journal:  Trends Mol Med       Date:  2017-04-17       Impact factor: 11.951

5.  Inhibition of tumor cell growth by overexpression of manganese-containing superoxide dismutase.

Authors:  L W Oberley
Journal:  Age (Omaha)       Date:  1998-04

Review 6.  Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases.

Authors:  Aaron K Holley; Lu Miao; Daret K St Clair; William H St Clair
Journal:  Antioxid Redox Signal       Date:  2014-02-14       Impact factor: 8.401

7.  A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability.

Authors:  Grace J Kim; Gary M Fiskum; William F Morgan
Journal:  Cancer Res       Date:  2006-11-01       Impact factor: 12.701

8.  Immunogold analysis of antioxidant enzymes in human renal cell carcinoma.

Authors:  T D Oberley; J M Sempf; M J Oberley; M L McCormick; K E Muse; L W Oberley
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

Review 9.  MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx.

Authors:  Demet Candas; Jian Jian Li
Journal:  Antioxid Redox Signal       Date:  2013-06-08       Impact factor: 8.401

10.  Pertussis toxin treatment alters manganese superoxide dismutase activity in lung. Evidence for lung oxygen toxicity in air-breathing rats.

Authors:  L B Clerch; G Neithardt; U Spencer; J A Melendez; G D Massaro; D Massaro
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808
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