Literature DB >> 1485884

Significance of adaptation mechanisms in adriamycin induced congestive heart failure.

P K Singal, N Siveski-Iliskovic, N Kaul, M Sahai.   

Abstract

Natural history of myocardial dysfunction due to chronic contractile deficit consists of physiological and pathophysiological adaptations culminating in congestive heart failure. Among the mechanisms considered is the combination of compensatory as well as the harmful overcompensatory role of the adrenergic system during the genesis of a congestive heart failure "spiral" due to the chronic treatment with adriamycin. Refractoriness of this spiral to various inotropic agents may involve reduced sympathetic support of the myocardium, structural loss of contractile elements and abnormalities of the Ca2+ metabolism.

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Year:  1992        PMID： 1485884     DOI： 10.1007/bf00788661

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  41 in total

Review 1.  Reflex control of the peripheral circulation.

Authors:  F M Abboud; D D Heistad; A L Mark; P G Schmid
Journal:  Prog Cardiovasc Dis       Date:  1976 Mar-Apr       Impact factor: 8.194

Review 2.  STUDIES ON THE FUNCTION OF THE ADRENERGIC NERVE ENDINGS IN THE HEART.

Authors:  E BRAUNWALD; C A CHIDSEY; D C HARRISON; T E GAFFNEY; R L KAHLER
Journal:  Circulation       Date:  1963-11       Impact factor: 29.690

Review 3.  The functional ambivalence of adaptive processes--considerations based on the example of the hemodynamically overloaded heart.

Authors:  R Jacob
Journal:  Basic Res Cardiol       Date:  1991       Impact factor: 17.165

4.  Ventricular beta-adrenoceptors in adriamycin-induced cardiomyopathy in the rabbit.

Authors:  E A Woodcock; L Arnolda; B P McGrath
Journal:  J Mol Cell Cardiol       Date:  1988-09       Impact factor: 5.000

5.  Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

Authors:  M R Bristow; R Ginsburg; V Umans; M Fowler; W Minobe; R Rasmussen; P Zera; R Menlove; P Shah; S Jamieson
Journal:  Circ Res       Date:  1986-09       Impact factor: 17.367

6.  Adriamycin cardiomyopathy in the rabbit: an animal model of low output cardiac failure with activation of vasoconstrictor mechanisms.

Authors:  L Arnolda; B McGrath; M Cocks; E Sumithran; C Johnston
Journal:  Cardiovasc Res       Date:  1985-06       Impact factor: 10.787

7.  Risk factors for doxorubicin-induced congestive heart failure.

Authors:  D D Von Hoff; M W Layard; P Basa; H L Davis; A L Von Hoff; M Rozencweig; F M Muggia
Journal:  Ann Intern Med       Date:  1979-11       Impact factor: 25.391

8.  Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin.

Authors:  R D Olson; J S MacDonald; C J vanBoxtel; R C Boerth; R D Harbison; A E Slonim; R W Freeman; J A Oates
Journal:  J Pharmacol Exp Ther       Date:  1980-11       Impact factor: 4.030

9.  Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.

Authors:  M R Bristow; R Ginsburg; W Minobe; R S Cubicciotti; W S Sageman; K Lurie; M E Billingham; D C Harrison; E B Stinson
Journal:  N Engl J Med       Date:  1982-07-22       Impact factor: 91.245

10.  Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure.

Authors:  W N Leimbach; B G Wallin; R G Victor; P E Aylward; G Sundlöf; A L Mark
Journal:  Circulation       Date:  1986-05       Impact factor: 29.690
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