Literature DB >> 14832399

Studies on immunity in anthrax. II. In vitro elaboration of protective antigen by non-proteolytic mutants of Bacillus anthracis.

G G WRIGHT, M A HEDBERG, R J FEINBERG.   

Abstract

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.

Entities:  

Keywords:  ANTHRAX; ANTIGENS AND ANTIBODIES; BACILLUS ANTHRACIS

Mesh：

Substances：

Year:  1951        PMID： 14832399      PMCID： PMC2136072          DOI： 10.1084/jem.93.6.523

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  2 in total

1.  Studies on infection with Bacillus anthracis; the production of an immunizing antigen in vitro.

Authors:  R J HECKLY; E GOLDWASSER
Journal:  J Infect Dis       Date:  1949 Jan-Feb       Impact factor: 5.226

2.  A PROTEOLYTIC ENZYME PRODUCED BY GROUP A STREPTOCOCCI WITH SPECIAL REFERENCE TO ITS EFFECT ON THE TYPE-SPECIFIC M ANTIGEN.

Authors:  S D Elliott
Journal:  J Exp Med       Date:  1945-06-01       Impact factor: 14.307
  2 in total
  13 in total

1.  Studies on immunity in anthrax. IV. Factors influencing elaboration of the protective antigen of bacillus antracis in chemically defined media.

Authors:  M PUZISS; G G WRIGHT
Journal:  J Bacteriol       Date:  1954-10       Impact factor: 3.490

2.  Studies on a protective antigen produced in vitro from Bacillus anthracis: medium and methods of production.

Authors:  F C BELTON; R E STRANGE
Journal:  Br J Exp Pathol       Date:  1954-04

3.  A method for collecting bacteria and their products from infections in experimental animals, with special reference to Bacillus anthracis.

Authors:  H SMITH; J KEPPIE; J L STANLEY
Journal:  Br J Exp Pathol       Date:  1953-10

4.  The chemical basis of the virulence of Bacillus anthracis. I. Properties of bacteria grown in vivo and preparation of extracts.

Authors:  H SMITH; J KEPPIE; J L STANLEY
Journal:  Br J Exp Pathol       Date:  1953-10

5.  Field Evaluation of a Human Anthrax Vaccine.

Authors:  P S Brachman; H Gold; S A Plotkin; F R Fekety; M Werrin; N R Ingraham
Journal:  Am J Public Health Nations Health       Date:  1962-04

6.  Nonproteolytic, avirulent Bacillus anthracis as a live vaccine.

Authors:  E S Fubra
Journal:  J Bacteriol       Date:  1966-03       Impact factor: 3.490

7.  Vaccine potencies of the live vaccine strain of Francisella tularensis and isolated bacterial components.

Authors:  P Hambleton; C G Evans; A M Hood; R E Strange
Journal:  Br J Exp Pathol       Date:  1974-08

8.  Cloning and expression of the Bacillus anthracis protective antigen gene in Bacillus subtilis.

Authors:  B E Ivins; S L Welkos
Journal:  Infect Immun       Date:  1986-11       Impact factor: 3.441

9.  Studies on immunity in anthrax. IX. Effect of variations in cultural conditions on elaboration of protective antigen by strains of Bacillus anthracis.

Authors:  G G WRIGHT; M PUZISS; W B NEELY
Journal:  J Bacteriol       Date:  1962-03       Impact factor: 3.490

10.  Studies on immunity in anthrax. VII. Carbohydrate metabolism of Bacillus anthracis in relation to elaboration of protective antigen.

Authors:  M PUZISS; G G WRIGHT
Journal:  J Bacteriol       Date:  1959-07       Impact factor: 3.490
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