Literature DB >> 1481626

The topography of microthrombi in ischemic brain infarct.

N Heye1, C Paetzold, R Steinberg, J Cervos-Navarro.   

Abstract

Following cerebral ischemia a tendency to increased coagulation can be detected. Vascular occlusion may develop either as a result of local thrombus formation or from emboli caused by circulating platelet aggregates. We studied the localization of microthrombi and their effects on tissue in double-hemisphere sections. Fresh brain infarcts showed a large number of microthrombi limited to the ischemic region. In more advanced infarcts they were found mainly at the border of the necrosis and diffusely distributed over both hemispheres. Older, subsiding infarcts showed only isolated microthrombi limited to the area of the necrosis. This indicates that great importance must be attached to microthrombi in infarct progression.

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Year:  1992        PMID： 1481626     DOI： 10.1111/j.1600-0404.1992.tb05122.x

Source DB:  PubMed          Journal:  Acta Neurol Scand        ISSN： 0001-6314            Impact factor:   3.209


  5 in total

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Authors:  Doodipala Samba Reddy; Aamir Bhimani; Ramkumar Kuruba; Min Jung Park; Farida Sohrabji
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2.  Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage.

Authors:  T F Choudhri; B L Hoh; C J Prestigiacomo; J Huang; L J Kim; A M Schmidt; W Kisiel; E S Connolly; D J Pinsky
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Authors:  Yuhang Jiang; Anna M Brynskikh; Devika S-Manickam; Alexander V Kabanov
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Review 4.  Can restoring incomplete microcirculatory reperfusion improve stroke outcome after thrombolysis?

Authors:  Turgay Dalkara; Ethem Murat Arsava
Journal:  J Cereb Blood Flow Metab       Date:  2012-10-10       Impact factor: 6.200

5.  Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.

Authors:  T F Choudhri; B L Hoh; H G Zerwes; C J Prestigiacomo; S C Kim; E S Connolly; G Kottirsch; D J Pinsky
Journal:  J Clin Invest       Date:  1998-10-01       Impact factor: 14.808
  5 in total

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