| Literature DB >> 1480324 |
U J Kang1, D H Park, T Wessel, H Baker, T H Joh.
Abstract
The source and site of the DOPA decarboxylation to dopamine in Parkinson's disease (PD) and animal models of PD are controversial. Since most of aromatic L-amino acid decarboxylase (AADC) are lost along with the degenerating dopaminergic neurons, we addressed the possibility that other decarboxylases or a novel protein that is structurally different from AADC decarboxylate L-DOPA in the denervated striatum. Immunotitration of the extracts from the denervated striatum with AADC antibody showed that all activity can be attributed to AADC-immunoreactive protein. We then investigated if there are non-dopaminergic intrinsic striatal neurons that express AADC. No evidence of such neurons was noted by immunocytochemistry and in situ hybridization.Entities:
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Year: 1992 PMID： 1480324 DOI： 10.1016/0304-3940(92)90773-z
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046