Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats.

Literature DB >> 1480208

An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats.

Abstract

Our data demonstrate the granulopoietic toxicity of aflatoxin B1 (AFB1) in vivo and show an impact of this mycotoxin on the production of some humoral regulatory factors dealing with the granulopoietic developmental pathway (CSA, IL-1, IL-2). The dose of AFB1 studied represented approximately 1/5 of LD50 for young male rats. An early suppressive effect of AFB1 towards CFU-GM was transient in treated animals. The peak in granulopoietic activity was preceded in time by an increased CSA and IL-1 formation. Elevated IL-2 synthesis and increased T cell activation paralleled the peak in granulopoietic activity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1480208 DOI： 10.1007/bf00578296

Source DB: PubMed Journal: Mycopathologia ISSN： 0301-486X Impact factor: 2.574

25 in total

Review 1. Polypeptides controlling hematopoietic cell development and activation. I. In vitro results.

Authors: F Herrmann; R Mertelsmann
Journal: Blut Date: 1989-03

Review 2. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

Authors: T R Mosmann; R L Coffman
Journal: Annu Rev Immunol Date: 1989 Impact factor: 28.527

3. Inhibition of human granulocyte-macrophage colony formation by interleukin 2-treated lymphocytes is mediated by interferon gamma and tumor necrosis factor alpha.

Authors: M Takahashi; K Oshimi; H Mizoguchi
Journal: Exp Hematol Date: 1990-06 Impact factor: 3.084

4. The effect of aflatoxin on chick-embryo liver cells.

Authors: K Terao
Journal: Exp Cell Res Date: 1967-10 Impact factor: 3.905

5. T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors: S Gillis; M M Ferm; W Ou; K A Smith
Journal: J Immunol Date: 1978-06 Impact factor: 5.422

6. The influence of the supernatant obtained from a culture of IL-2-activated lymphocytes on human hematopoietic progenitors.

Authors: Y Iizuka; M Endo; A Horikoshi; J Takeuchi; T Ohshima
Journal: Exp Hematol Date: 1990-02 Impact factor: 3.084

7. Effects of aflatoxin on lymphoid cells of weanling rat.

Authors: K P Singh; S I Zaidi; A K Saxena; P K Ray
Journal: J Appl Toxicol Date: 1990-08 Impact factor: 3.446

8. The in vitro effects of trichothecenes on the immune system.

Authors: K Miller; H A Atkinson
Journal: Food Chem Toxicol Date: 1986 Jun-Jul Impact factor: 6.023

9. Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients.

Authors: S E Ettinghausen; J G Moore; D E White; L Platanias; N S Young; S A Rosenberg
Journal: Blood Date: 1987-06 Impact factor: 22.113