Literature DB >> 1480182

Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family.

C M Jones1, D Simon-Chazottes, J L Guenet, B L Hogan.   

Abstract

A cDNA clone, Vgr-2, with homology to certain members of the transforming growth factor-beta superfamily has been isolated from a mouse embryo cDNA library. The encoded protein shows significant similarity to members of the Vg-1/decapentaplegic/bone morphogenetic protein subgroup of the transforming growth factor-beta family. Within this group, Vgr-2 is more similar to Xenopus Vg-1 than to any other member so far isolated. The gene is expressed at highest levels during midgestation mouse development, and transcripts are localized by in situ hybridization to the osteogenic zone of developing bone. Vgr-2 is expressed in F9 teratocarcinoma cells, and its RNA levels are down-regulated within 24 h after differentiation with retinoic acid. The genomic organization of Vgr-2 and its location on mouse chromosome 6 are reported.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1480182     DOI： 10.1210/mend.6.11.1480182

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  10 in total

1.  FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development.

Authors:  Aaron B Steiner; Mark J Engleka; Qun Lu; Eileen C Piwarzyk; Sergey Yaklichkin; Julie L Lefebvre; James W Walters; Liliam Pineda-Salgado; Patricia A Labosky; Daniel S Kessler
Journal:  Development       Date:  2006-11-08       Impact factor: 6.868

2.  Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.

Authors:  R Kothapalli; I Buyuksal; S Q Wu; N Chegini; S Tabibzadeh
Journal:  J Clin Invest       Date:  1997-05-15       Impact factor: 14.808

3.  An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma.

Authors:  Nobuyuki Ehira; Hiroyuki Oshiumi; Misako Matsumoto; Takeshi Kondo; Masahiro Asaka; Tsukasa Seya
Journal:  J Exp Clin Cancer Res       Date:  2010-10-15

4.  Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

Authors:  E Gazzerro; V Gangji; E Canalis
Journal:  J Clin Invest       Date:  1998-12-15       Impact factor: 14.808

5.  Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity.

Authors:  Olov Andersson; Marion Korach-Andre; Eva Reissmann; Carlos F Ibáñez; Philippe Bertolino
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-14       Impact factor: 11.205

6.  Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose.

Authors:  Joseph J Shen; Lihua Huang; Liunan Li; Carolina Jorgez; Martin M Matzuk; Chester W Brown
Journal:  Mol Endocrinol       Date:  2008-11-13

7.  SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

Authors:  D B Constam; M Calfon; E J Robertson
Journal:  J Cell Biol       Date:  1996-07       Impact factor: 10.539

8.  Functional and In Silico Assessment of GDF3 Gene Variants in a Chinese Congenital Scoliosis Population.

Authors:  Jia Chen; Xiaoxin Li; Yuchen Niu; Zhihong Wu; Guixing Qiu
Journal:  Med Sci Monit       Date:  2018-05-08

9.  Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.

Authors:  S E Gitelman; M S Kobrin; J Q Ye; A R Lopez; A Lee; R Derynck
Journal:  J Cell Biol       Date:  1994-09       Impact factor: 10.539

10.  Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals.

Authors:  Juan C Opazo; Kattina Zavala
Journal:  Sci Rep       Date:  2018-09-11       Impact factor: 4.379
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.