| Literature DB >> 1479579 |
D B Capps1, J Dunbar, S R Kesten, J Shillis, L M Werbel, J Plowman, D L Ward.
Abstract
2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with [(alkylamino)alkyl]hydrazines. Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia. Advanced studies led to the selection of 3bbb for clinical trial.Entities:
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Year: 1992 PMID： 1479579 DOI： 10.1021/jm00104a001
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446