Literature DB >> 1479151

In vitro effect of hCG on steroidogenesis in the testicular tissue from a patient with complete androgen resistance.

A M Ronco1, L E Valladares, L Devoto, A Ahumada, A M Pino.   

Abstract

The present study was performed to determine the in vitro steroidogenic capacity of a gonadal sample from a patient suffering from a complete androgen resistance syndrome. Testosterone and estradiol production by the testicular tissue from this patient as well as gonadotropin binding to a membrane fraction prepared from this tissue were measured. hCG bound with high affinity but with a very low capacity and the gonadotropin induced a clear dose response for both testosterone and estradiol production. The ED50 of hCG on testosterone and estradiol production were 2.5 and 5.0 nM, respectively. We conclude that estradiol originates from Leydig cell activity, since estradiol synthesis does not depend on testosterone availability and it shows a clear hCG dose response.

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Year:  1992        PMID： 1479151     DOI： 10.1007/BF03345817

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  20 in total

1.  Studies of the human testis. X. Properties of human chorionic gonadotropin receptor in adult testis and relation to intratesticular testosterone concentration.

Authors:  A F Hsu; D Stratico; M Hosaka; P Troen
Journal:  J Clin Endocrinol Metab       Date:  1978-09       Impact factor: 5.958

2.  Aromatase activity in genital skin fibroblasts from normal and androgen-insensitive individuals.

Authors:  S C Stillman; B A Evans; I A Hughes
Journal:  J Endocrinol       Date:  1990-10       Impact factor: 4.286

3.  Steroid metabolism in the gonads of a patient with testicular feminization. I. Metabolism of cholesterol, pregnenolone, progesterone and dehydroepiandrosterone in vitro.

Authors:  A E Schindler
Journal:  Endokrinologie       Date:  1975-07

4.  Effects of hCG and cyclic AMP on aromatization in purified Leydig cells of immature and mature rats.

Authors:  L E Valladares; A H Payne
Journal:  Biol Reprod       Date:  1981-11       Impact factor: 4.285

5.  Testicular luteinizing hormone receptor content and in vitro stimulation of cyclic adenosine 3',5'-monophosphate and steroid production: a comparison between man and rat.

Authors:  I Huhtaniemi; N Bolton; P Leinonen; M Kontturi; R Vihko
Journal:  J Clin Endocrinol Metab       Date:  1982-11       Impact factor: 5.958

6.  Studies of in vitro steroid metabolism by testis tissue from 'complete' and 'incomplete' forms of testicular feminization.

Authors:  J B Bell
Journal:  Clin Endocrinol (Oxf)       Date:  1975-07       Impact factor: 3.478

7.  Internalization and recycling of lutropin receptors upon stimulation by porcine lutropin and human choriogonadotropin in porcine Leydig cells.

Authors:  N Genty; R Salesse; J Garnier
Journal:  Biol Cell       Date:  1987       Impact factor: 4.458

8.  Low aromatase activity and gene expression in human fetal testes.

Authors:  J Tapanainen; R Voutilainen; R B Jaffe
Journal:  J Steroid Biochem       Date:  1989-07       Impact factor: 4.292

9.  Rapid and slow response of human testicular steroidogenesis to hCG by measurements of steroids in spermatic and peripheral vein blood.

Authors:  H Martikainen; I Huhtaniemi; O Lukkarinen; R Vihko
Journal:  J Steroid Biochem       Date:  1982-02       Impact factor: 4.292

10.  Origin of estrogen in normal men and in women with testicular feminization.

Authors:  P C MacDonald; J D Madden; P F Brenner; J D Wilson; P K Siiteri
Journal:  J Clin Endocrinol Metab       Date:  1979-12       Impact factor: 5.958
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  1 in total

1.  Effects of abstinence on sex hormone profile in alcoholic patients without liver failure.

Authors:  H Iturriaga; L Valladares; S Hirsch; E Devoto; C P'erez; D Bunout; X Lioi; M Petermann
Journal:  J Endocrinol Invest       Date:  1995-09       Impact factor: 4.256
  1 in total

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