Literature DB >> 1478653

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR.

D J Vandenbergh1, A M Persico, A L Hawkins, C A Griffin, X Li, E W Jabs, G R Uhl.   

Abstract

The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3' untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

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Year:  1992        PMID： 1478653     DOI： 10.1016/s0888-7543(05)80138-7

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  171 in total

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4.  Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls.

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5.  Absence of linkage for schizophrenia on the short arm of chromosome 5 in multiplex Canadian families.

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8.  Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter.

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10.  Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations.

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Journal:  Neurol Sci       Date:  2009-09-25       Impact factor: 3.307
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