Urethral tube graft in dogs: prosthesis of dacron lined silicone.

Silicone urethral prostheses lined with dacron velour were used for urethral replacement in eight mongrel dogs. In five of these prostheses the silicone was lined on the outside, and in three on the inside and outside. Seven dogs survived, one of which is still under observation at 10 months. Findings of excretory urography at the time of sacrifice were normal. In four cases urethrography showed significant flow around as well as through the prosthesis. In all instances study of urethral histologic sections showed complete encasement of the prosthesis by regenerated epithelium. A dacron lined silicone prosthesis can thus serve as an effective total urethral replacement in animals and may be used clinically in the future.