| Literature DB >> 1478255 |
R M Kessler1, N S Mason, J R Votaw, T De Paulis, J A Clanton, M S Ansari, D E Schmidt, R G Manning, R L Bell.
Abstract
[123I]Epidepride, a potent and selective dopamine D2 radioligand, was administered to a 27 year old normal male volunteer. Single photon tomography revealed that peak striatal uptake occurred at 4 h after injection with a striatal:cerebellar ratio of 7.8 rising to over 100 at 18 h post injection. Uptake above the levels seen in cerebellum was also noted in the thalamus, pituitary, hypothalamus and temporal lobe, particularly medially. Single photon tomography with [123I]epidepride allows visualization of extrastriatal dopamine D2 receptors in man.Entities:
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Year: 1992 PMID： 1478255 DOI： 10.1016/0014-2999(92)90825-o
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432