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Literature DB >> 14778915

Studies on peroxidative detoxification of purified diphtheria toxin.

Abstract

The mechanism of the peroxidative oxidation of diphtheria toxin has been investigated. It has been found that this reaction requires the presence of an oxidizable, dialyzable cofactor in addition to hydrogen peroxide and peroxidase. Cofactors are present in a variety of materials and have been partially purified from urine. The flocculation titer of toxin modified by peroxidation remains unchanged even after 99 per cent or more of the toxicity has been destroyed. The change thus appears analogous to the conversion of toxin to toxoid in the presence of formalin. It is suggested that the well known conversion of crude diphtheria toxin to toxoid which occurs on storage or aging may be due to a slow peroxidative process.

Entities: Chemical Disease

Keywords: DIPHTHERIA

Mesh：

Substances：

Year: 1950 PMID： 14778915 PMCID： PMC2136044 DOI： 10.1084/jem.92.4.337

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

3 in total

1. Studies on Diphtheria Toxin and Its Reaction with Antitoxin.

Authors: A M Pappenheimer
Journal: J Bacteriol Date: 1942-03 Impact factor: 3.490

2. The Purification and Concentration of Diphtheria Toxin: I. Evaluation of Previous Methods; Description of a New Procedure.

Authors: M D Eaton
Journal: J Bacteriol Date: 1936-04 Impact factor: 3.490

3. The Isolation and Crystallization of Tetanal Toxin.

Authors: L Pillemer; R Wittler; D B Grossberg
Journal: Science Date: 1946-05-17 Impact factor: 47.728

3 in total

11 in total

8. Endogenous peroxidase activity in brush cell-like cells in the large intestine of the bullfrog tadpole, Rana catesbeiana.

Authors: K Sugimoto; Y Ichikawa; I Nakamura
Journal: Cell Tissue Res Date: 1983 Impact factor: 5.249

9. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.

Authors: R I Lehrer; M J Cline
Journal: J Clin Invest Date: 1969-08 Impact factor: 14.808

10. Role of the phagocyte in host-parasite interactions. 8. Effect of whole-body x-irradiation on nicotinamides, lysosomal enzymes and bactericidal activities of leukocytes during phagocytosis.

Authors: R J Selvaraj; A J Sbarra
Journal: J Bacteriol Date: 1967-07 Impact factor: 3.490

Studies on peroxidative detoxification of purified diphtheria toxin.

1. Studies on Diphtheria Toxin and Its Reaction with Antitoxin.

2. The Purification and Concentration of Diphtheria Toxin: I. Evaluation of Previous Methods; Description of a New Procedure.

3. The Isolation and Crystallization of Tetanal Toxin.

1. A reinvestigation of the diphtheria toxin-antitoxin flocculation reaction using 355-methionine-labelled toxin.

2. Increasing color density with decreasing toxicity of tetanus toxin in the Mueller medium.

3. Myeloperoxidase-oxidase oxidation of cysteamine.

4. Oxidative inactivation of Actinobacillus actinomycetemcomitans leukotoxin by the neutrophil myeloperoxidase system.

Review 5. Myeloperoxidase in human neutrophil host defence.

Review 6. Corynebacterium diphtheriae and its relatives.

7. Antifungal effects of peroxidase systems.

8. Endogenous peroxidase activity in brush cell-like cells in the large intestine of the bullfrog tadpole, Rana catesbeiana.

9. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.

10. Role of the phagocyte in host-parasite interactions. 8. Effect of whole-body x-irradiation on nicotinamides, lysosomal enzymes and bactericidal activities of leukocytes during phagocytosis.