BACKGROUND: Previous research has indicated a role for serotonin (5-HT) in the anterior uvea of the eye. The purpose of this study was to examine whether mRNAs encoding particular 5-HT receptors are expressed in the ciliary body and iris of a number of human subjects. METHODS: The presence of mRNA encoding 5-HT receptors in four human ciliary body samples was determined by reverse transcription-polymerase chain reaction experiments using a standard methodology. RESULTS: Positive signals for 5-HT(1A), 5-HT(2A), 5-HT(2B), 5-HT(2C) and 5-HT(7) receptor mRNAs were detected in the samples prepared from various human ciliary body samples. CONCLUSION: The detection of certain 5-HT receptor mRNAs in the human ciliary body supports the hypothesis that serotonin is involved in the control of aqueous dynamics and indicates that ligands acting on these 5-HT receptors may have potential use as intraocular pressure-lowering agents.
BACKGROUND: Previous research has indicated a role for serotonin (5-HT) in the anterior uvea of the eye. The purpose of this study was to examine whether mRNAs encoding particular 5-HT receptors are expressed in the ciliary body and iris of a number of human subjects. METHODS: The presence of mRNA encoding 5-HT receptors in four human ciliary body samples was determined by reverse transcription-polymerase chain reaction experiments using a standard methodology. RESULTS: Positive signals for 5-HT(1A), 5-HT(2A), 5-HT(2B), 5-HT(2C) and 5-HT(7) receptor mRNAs were detected in the samples prepared from various human ciliary body samples. CONCLUSION: The detection of certain 5-HT receptor mRNAs in the human ciliary body supports the hypothesis that serotonin is involved in the control of aqueous dynamics and indicates that ligands acting on these 5-HT receptors may have potential use as intraocular pressure-lowering agents.
Authors: F Veglio; U De Sanctis; D Schiavone; S Cavallone; P Mulatero; F M Grignolo; L Chiandussi Journal: Ophthalmologica Date: 1998 Impact factor: 3.250
Authors: Jesse A May; Marsha A McLaughlin; Najam A Sharif; Mark R Hellberg; Thomas R Dean Journal: J Pharmacol Exp Ther Date: 2003-04-03 Impact factor: 4.030
Authors: L Noehr-Jensen; S T Zwisler; F Larsen; S H Sindrup; P Damkier; F Nielsen; K Brosen Journal: Eur J Clin Pharmacol Date: 2009-04-29 Impact factor: 2.953