K J Thong1, D T Baird. 1. Department of Obstetrics and Gynaecology, University of Edinburgh, UK.
Abstract
OBJECTIVE: To investigate the clinical efficacy of the combination of mifepristone and an orally active prostaglandin, misoprostol, for early medical termination. DESIGN: Women with amenorrhoea < or = 56 days were given 200 mg mifepristone. 48 h later, 600 micrograms misoprostol was given orally. SETTING: Medical Termination Unit, Simpson Memorial Maternity Pavilion, Edinburgh. SUBJECTS: 100 women requesting medical termination of pregnancy. INTERVENTIONS: Evacuation of uterus for incomplete abortion or on-going pregnancies. RESULTS: One woman had an incomplete abortion prior to administration of misoprostol. 92 (93%) out of 99 women had complete abortion following administration of misoprostol. There were three on-going pregnancies (3.0%, 95% confidence limits (CL) 0.6-8.6) and four incomplete abortions with this regimen (4.0%, 95% CL 1.1-10.0). 24% women vomited and 7% had diarrhoea following administration of misoprostol. 62% did not require any analgesia. CONCLUSIONS: The combination of misoprostol with mifepristone is inexpensive, simple, effective, noninvasive and an acceptable alternative to current regimens for medical termination.
OBJECTIVE: To investigate the clinical efficacy of the combination of mifepristone and an orally active prostaglandin, misoprostol, for early medical termination. DESIGN:Women with amenorrhoea < or = 56 days were given 200 mg mifepristone. 48 h later, 600 micrograms misoprostol was given orally. SETTING: Medical Termination Unit, Simpson Memorial Maternity Pavilion, Edinburgh. SUBJECTS: 100 women requesting medical termination of pregnancy. INTERVENTIONS: Evacuation of uterus for incomplete abortion or on-going pregnancies. RESULTS: One woman had an incomplete abortion prior to administration of misoprostol. 92 (93%) out of 99 women had complete abortion following administration of misoprostol. There were three on-going pregnancies (3.0%, 95% confidence limits (CL) 0.6-8.6) and four incomplete abortions with this regimen (4.0%, 95% CL 1.1-10.0). 24% womenvomited and 7% had diarrhoea following administration of misoprostol. 62% did not require any analgesia. CONCLUSIONS: The combination of misoprostol with mifepristone is inexpensive, simple, effective, noninvasive and an acceptable alternative to current regimens for medical termination.
Entities:
Keywords:
Abortion, Drug Induced; Abortion, Induced; Biology; Clinical Research; Developed Countries; Endocrine System; Europe; Family Planning; Fertility Control, Postconception; Hormone Antagonists; Hormones; Misoprostol; Northern Europe; Physiology; Prostaglandins; Prostaglandins, Synthetic; Research Report; Ru-486; Scotland; United Kingdom
Authors: Miha Lucovnik; Ruben J Kuon; Linda R Chambliss; William L Maner; Shao-Qing Shi; Leili Shi; James Balducci; Robert E Garfield Journal: Acta Obstet Gynecol Scand Date: 2011-06-27 Impact factor: 3.636
Authors: Shagufta Parveen; Zaffar Abbas Khateeb; S M Mufti; M A Shah; Vishal R Tandon; S Hakak; Z Singh; Shagufta Yasmeen; Shakeel A Mir; Rehana Tabasum; Nasreen Jan Journal: Indian J Pharmacol Date: 2011-04 Impact factor: 1.200