Literature DB >> 14769549

Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents.

B Colley1, K Tucker, D A Fadool.   

Abstract

Activation of the receptor tyrosine kinase (RTK), insulin (IRK) or neurotrophin B (TrkB), was characterized and compared in olfactory bulb neuron (OBN) cultures from Sprague Dawley rats and sv129 B6 mice. Current suppression attributed to modulation of the delayed rectifier, Kv1.3, a voltage-gated potassium (Kv) channel of the Shaker family, was observed following acute application of the growth factors, insulin or brain-derived neurotrophic factor (BDNF), to mitral cells of either rodent model. Using site-directed mutagenesis of putative tyrosine phosphorylation recognition motifs in the channel, we find that stimulation of Kv1.3 with these growth factors causes multiple phosphorylation, albeit via different residue combinations that are RTK specific.

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Year:  2004        PMID： 14769549      PMCID： PMC3082840     

Source DB:  PubMed          Journal:  Receptors Channels        ISSN： 1060-6823


  39 in total

Review 1.  The protein kinase complement of the human genome.

Authors:  G Manning; D B Whyte; R Martinez; T Hunter; S Sudarsanam
Journal:  Science       Date:  2002-12-06       Impact factor: 47.728

Review 2.  Modulation of ion channels by protein phosphorylation and dephosphorylation.

Authors:  I B Levitan
Journal:  Annu Rev Physiol       Date:  1994       Impact factor: 19.318

Review 3.  Synaptic transmission and modulation in the olfactory bulb.

Authors:  P Q Trombley; G M Shepherd
Journal:  Curr Opin Neurobiol       Date:  1993-08       Impact factor: 6.627

4.  Potassium channels and their evolving gates.

Authors:  L Y Jan; Y N Jan
Journal:  Nature       Date:  1994-09-08       Impact factor: 49.962

Review 5.  Protein tyrosine kinase structure and function.

Authors:  S R Hubbard; J H Till
Journal:  Annu Rev Biochem       Date:  2000       Impact factor: 23.643

6.  Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases.

Authors:  M R Bowlby; D A Fadool; T C Holmes; I B Levitan
Journal:  J Gen Physiol       Date:  1997-11       Impact factor: 4.086

7.  Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system.

Authors:  F Folli; L Bonfanti; E Renard; C R Kahn; A Merighi
Journal:  J Neurosci       Date:  1994-11       Impact factor: 6.167

8.  Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent.

Authors:  K Tucker; D A Fadool
Journal:  J Physiol       Date:  2002-07-15       Impact factor: 5.182

9.  Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.

Authors:  M Garcia-Calvo; R J Leonard; J Novick; S P Stevens; W Schmalhofer; G J Kaczorowski; M L Garcia
Journal:  J Biol Chem       Date:  1993-09-05       Impact factor: 5.157

10.  [125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain.

Authors:  H G Knaus; R O Koch; A Eberhart; G J Kaczorowski; M L Garcia; R S Slaughter
Journal:  Biochemistry       Date:  1995-10-17       Impact factor: 3.162
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  30 in total

1.  Endocytosis as a mechanism for tyrosine kinase-dependent suppression of a voltage-gated potassium channel.

Authors:  Edmund Nesti; Brian Everill; Anthony D Morielli
Journal:  Mol Biol Cell       Date:  2004-06-23       Impact factor: 4.138

2.  The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice.

Authors:  Songqing Lu; Paromita Das; Debra A Fadool; Leonard K Kaczmarek
Journal:  J Neurophysiol       Date:  2010-04-14       Impact factor: 2.714

Review 3.  Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart.

Authors:  Vahagn Ohanyan; Liya Yin; Raffi Bardakjian; Christopher Kolz; Molly Enrick; Tatevik Hakobyan; Jordan Luli; Kathleen Graham; Mohamed Khayata; Suzanna Logan; John Kmetz; William M Chilian
Journal:  Microcirculation       Date:  2017-05       Impact factor: 2.628

Review 4.  Olfaction under metabolic influences.

Authors:  Brigitte Palouzier-Paulignan; Marie-Christine Lacroix; Pascaline Aimé; Christine Baly; Monique Caillol; Patrice Congar; A Karyn Julliard; Kristal Tucker; Debra Ann Fadool
Journal:  Chem Senses       Date:  2012-07-25       Impact factor: 3.160

5.  Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury.

Authors:  Thomas M Reeves; Patricia A Trimmer; Beverly S Colley; Linda L Phillips
Journal:  Exp Neurol       Date:  2016-06-11       Impact factor: 5.330

6.  Diet-induced obesity resistance of Kv1.3-/- mice is olfactory bulb dependent.

Authors:  K Tucker; J M Overton; D A Fadool
Journal:  J Neuroendocrinol       Date:  2012-08       Impact factor: 3.627

7.  Electrophysiological and behavioral phenotype of insulin receptor defective mice.

Authors:  P Das; A D Parsons; J Scarborough; J Hoffman; J Wilson; R N Thompson; J M Overton; D A Fadool
Journal:  Physiol Behav       Date:  2005-09-19

8.  Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel.

Authors:  Kristal Tucker; Sukhee Cho; Nicolas Thiebaud; Michael X Henderson; Debra Ann Fadool
Journal:  J Physiol       Date:  2013-03-11       Impact factor: 5.182

9.  Post-synaptic density perturbs insulin-induced Kv1.3 channel modulation via a clustering mechanism involving the SH3 domain.

Authors:  D R Marks; D A Fadool
Journal:  J Neurochem       Date:  2007-09-13       Impact factor: 5.372

10.  Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.

Authors:  Beverly S Colley; Melissa A Cavallin; Kc Biju; David R Marks; Debra A Fadool
Journal:  BMC Neurosci       Date:  2009-01-23       Impact factor: 3.288
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