Studies on thiazolopyridines--a novel synthesis of bis-thiazolopyridines as promising antimicrobial agents.

A variety of novel bis-thiazolopyridine derivatives 4a-e were synthesized via the reaction of bis-thiazolinone 3 with different arylcinnamonitrile derivatives (1:2 molar ratio), whereas the reaction of bis-compounds 7a-e with malononitrile in ethanol solution containing a few drops of piperidine afforded the novel bis-thiazolopyridines 8a-e. The structures of the synthesized compounds were established by elemental analyses and spectral data. Some of the newly synthesized compounds show moderate to high antimicrobial activity.