Literature DB >> 1476791

The effect of drug exposure on thyroid hormone levels of newborns.

J T Hernandez1, L Hoffman, S Weavil, S Cvejin, A J Prange.   

Abstract

This study examines the effect of women's alcohol abuse during pregnancy on the thyroid-stimulating hormone (TSH) and thyroxine (T4) levels of their babies at birth. Forty-seven babies were born to mothers identified as substance abusers. Maternal use of marijuana and/or cocaine did not result in newborns' TSH and T4 hormone levels being significantly different from non-substance-abusing controls' TSH and T4 levels. Alcohol use, however, was significantly linked to lower newborn TSH levels, lower than TSH levels of a control sample of newborns whose mothers used marijuana and/or cocaine, and lower than a control sample of newborns whose mothers abused no substances. This finding suggests further investigation of possible links between thyroid functioning and fetal alcohol syndrome (FAS).

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Year:  1992        PMID: 1476791     DOI: 10.1016/0885-4505(92)90072-7

Source DB:  PubMed          Journal:  Biochem Med Metab Biol        ISSN: 0885-4505


  5 in total

1.  Thyroxine administration prevents matrilineal intergenerational consequences of in utero ethanol exposure in rats.

Authors:  Elif Tunc-Ozcan; Kathryn M Harper; Evan N Graf; Eva E Redei
Journal:  Horm Behav       Date:  2016-04-16       Impact factor: 3.587

2.  Maternal adrenocorticotropin, cortisol, and thyroid hormone responses to all three-trimester equivalent repeated binge alcohol exposure: ovine model.

Authors:  Jayanth Ramadoss; Ursula Tress; Wei-Jung A Chen; Timothy A Cudd
Journal:  Alcohol       Date:  2008-05       Impact factor: 2.405

3.  Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression.

Authors:  Elif Tunc-Ozcan; Timothy M Ullmann; Pradeep K Shukla; Eva E Redei
Journal:  Alcohol Clin Exp Res       Date:  2013-06-13       Impact factor: 3.455

4.  Thyroid Function in Pregnant Women With Moderate to Severe Alcohol Consumption Is Related to Infant Developmental Outcomes.

Authors:  Kirsten A Donald; Catherine J Wedderburn; Whitney Barnett; Nadia Hoffman; Heather J Zar; Eva E Redei; Dan J Stein
Journal:  Front Endocrinol (Lausanne)       Date:  2018-06-05       Impact factor: 5.555

5.  Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.

Authors:  E Tunc-Ozcan; S L Wert; P H Lim; A Ferreira; E E Redei
Journal:  Mol Psychiatry       Date:  2017-07-20       Impact factor: 15.992

  5 in total

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