Literature DB >> 14765244

Enantioselective Friedel-Crafts reaction of indoles with arylidene malonates catalyzed by iPr-bisoxazoline-Cu(OTf)2.

Jian Zhou1, Yong Tang.   

Abstract

The cheap and simple (i)Pr-bisoxazoline-Cu(OTf)(2) proves to be an efficient catalyst in the asymmetric Friedel-Crafts reaction of indole with arylidene malonates. In (i)BuOH, the S-enantiomer was obtained in up to 97% ee, while the opposite enantiomer was obtained in up to 78% ee in CH(2)Cl(2) or TTCE.

Entities:  

Year:  2004        PMID： 14765244     DOI： 10.1039/b313197a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters.

Authors:  Shaofeng Duan; Ranjan Jana; Jon A Tunge
Journal:  J Org Chem       Date:  2009-06-19       Impact factor: 4.354

2.  Dynamic control of chirality in phosphine ligands for enantioselective catalysis.

Authors:  Depeng Zhao; Thomas M Neubauer; Ben L Feringa
Journal:  Nat Commun       Date:  2015-03-25       Impact factor: 14.919

3.  Synthesis of new C2- symmetric fluoren-9-ylidene malonate derived bis(oxazoline) ligands and their application in Friedel-Crafts reactions.

Authors:  Jing Li; Hong-Liang Chen; Lei Liu; Bin Fu
Journal:  Molecules       Date:  2010-11-26       Impact factor: 4.411
  3 in total

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