Literature DB >> 14764698

Reduced thymocyte development in sonic hedgehog knockout embryos.

Divya K Shah1, Ariadne L Hager-Theodorides, Susan V Outram, Susan E Ross, Alberto Varas, Tessa Crompton.   

Abstract

The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells.

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Year:  2004        PMID： 14764698     DOI： 10.4049/jimmunol.172.4.2296

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  30 in total

1.  Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells.

Authors:  Renee M Laird; Karen Laky; Sandra M Hayes
Journal:  J Immunol       Date:  2010-10-25       Impact factor: 5.422

2.  Smoothened is a fully competent activator of the heterotrimeric G protein G(i).

Authors:  Feng Shen; Lan Cheng; Andrew E Douglas; Natalia A Riobo; David R Manning
Journal:  Mol Pharmacol       Date:  2013-01-04       Impact factor: 4.436

3.  Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease.

Authors:  Cynthia D Guy; Ayako Suzuki; Marzena Zdanowicz; Manal F Abdelmalek; James Burchette; Aynur Unalp; Anna Mae Diehl
Journal:  Hepatology       Date:  2012-04-18       Impact factor: 17.425

Review 4.  Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.

Authors:  Chi Young Ok; Rajesh Ramachandra Singh; Francisco Vega
Journal:  Am J Pathol       Date:  2011-11-01       Impact factor: 4.307

5.  Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog.

Authors:  Ching-in Lau; Susan V Outram; José Ignacio Saldaña; Anna L Furmanski; Johannes T Dessens; Tessa Crompton
Journal:  Blood       Date:  2012-03-28       Impact factor: 22.113

6.  Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.

Authors:  Mark Merchant; Marie Evangelista; Shiuh-Ming Luoh; Gretchen D Frantz; Sreedevi Chalasani; Richard A D Carano; Marjie van Hoy; Julio Ramirez; Annie K Ogasawara; Leanne M McFarland; Ellen H Filvaroff; Dorothy M French; Frederic J de Sauvage
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

7.  The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.

Authors:  Ariadne L Hager-Theodorides; Johannes T Dessens; Susan V Outram; Tessa Crompton
Journal:  Blood       Date:  2005-04-26       Impact factor: 22.113

8.  Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism.

Authors:  Nicola J Rowbotham; Ariadne L Hager-Theodorides; Anna L Furmanski; Susan E Ross; Susan V Outram; Johannes T Dessens; Tessa Crompton
Journal:  Blood       Date:  2009-03-09       Impact factor: 22.113

9.  Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in altered thymocyte development.

Authors:  Miranda L Hanson; Kathleen M Brundage; Rosana Schafer; Janet C Tou; John B Barnett
Journal:  Toxicol Appl Pharmacol       Date:  2009-10-08       Impact factor: 4.219

10.  Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.

Authors:  Ekati Drakopoulou; Susan V Outram; Nicola J Rowbotham; Susan E Ross; Anna L Furmanski; Jose Ignacio Saldana; Ariadne L Hager-Theodorides; Tessa Crompton
Journal:  Cell Cycle       Date:  2010-10-27       Impact factor: 4.534
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