BACKGROUND: Truly long term survival post heart transplantation has become increasingly frequent over the past two decades. METHODS: We analyzed multiple clinical outcomes in the cohort of 140 patients in the Stanford database who underwent heart transplantation after the introduction of cyclosporine-based immunosuppression in 1980 and survived >10 years after transplantation. RESULTS: We found generally excellent functional status in these patients, but a high incidence of hypertension, renal dysfunction, and graft CAD as well as malignancy. CONCLUSION: With continued improvement in post-transplant survival rates, providing complex care for such long-term recipients as these will assume increasing clinical importance in the everyday practice of transplant medicine and these data highlight the problems to be anticipated.
BACKGROUND: Truly long term survival post heart transplantation has become increasingly frequent over the past two decades. METHODS: We analyzed multiple clinical outcomes in the cohort of 140 patients in the Stanford database who underwent heart transplantation after the introduction of cyclosporine-based immunosuppression in 1980 and survived >10 years after transplantation. RESULTS: We found generally excellent functional status in these patients, but a high incidence of hypertension, renal dysfunction, and graft CAD as well as malignancy. CONCLUSION: With continued improvement in post-transplant survival rates, providing complex care for such long-term recipients as these will assume increasing clinical importance in the everyday practice of transplant medicine and these data highlight the problems to be anticipated.
Authors: Otavio Rizzi Coelho-Filho; Ravi Shah; Carlos Fernando Ramos Lavagnoli; Jose Carlos Barros; Tomas G Neilan; Venkatesh L Murthy; Pedro Paulo Martins de Oliveira; Jose Roberto Matos Souza; Elaine Soraya Barbosa de Oliveira Severino; Karlos Alexandre de Souza Vilarinho; Lindemberg da Mota Silveira Filho; Jose Garcia; Marc J Semigran; Otavio Rizzi Coelho; Michael Jerosch-Herold; Orlando Petrucci Journal: Int J Cardiovasc Imaging Date: 2016-07-20 Impact factor: 2.357