Literature DB >> 14761665

Anti-inflammatory activity of tea (Camellia sinensis) root extract.

P Chattopadhyay1, S E Besra, A Gomes, M Das, P Sur, S Mitra, J R Vedasiromoni.   

Abstract

Pharmacological studies were carried out with methanol-water (1:1) extract of dried tea (Camellia sinensis) root extract (TRE). TRE was found to possess anti-inflammatory, analgesic and antipyretic activities at 1/10th of its LD50 dose of 100 mg/kg i.p. It was found that TRE inhibited the arachidonic acid-induced paw oedema in rats which indicated that TRE produced the anti-inflammatory activity by inhibiting both the cyclooxygenase and lypooxygenase pathways of arachidonic acid metabolism. TRE also enhanced peritoneal cell count and the number of macrophages in normal mice. It is plausible that the saponins present in TRE may be responsible for these activities of TRE.

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Year:  2004        PMID： 14761665     DOI： 10.1016/j.lfs.2003.07.053

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


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