| Literature DB >> 14761198 |
Abdulkareem Melaiye1, Richard S Simons, Amy Milsted, Francesco Pingitore, Chrys Wesdemiotis, Claire A Tessier, Wiley J Youngs.
Abstract
Silver(I)-2,6-bis(ethanolimidazolemethyl)pyridine hydroxide (4a) and silver(I)-2,6-bis(propanolimidazolemethyl)pyridine hydroxide (4b) are water-soluble silver(I)-carbene complexes that were synthesized in high yield by reacting silver(I) oxide with N-substituted pincer ligands 3 (a = 2,6-bis(ethanolimidazoliummethyl)pyridine diiodide, b = 2,6-bis(propanolimidazoliummethylpyridine)pyridine dibromide). The X-ray crystal structure of 4a is a one-dimensional linear polymer, whereas the mass spectroscopy confirms a monomer in the gas phase. A change in the anion of 4a from a hydroxide to a hexafluorophosphate formed a silver(I)-carbene complex 4c that is dimeric in structure and insoluble in water. The bactericidal activities of the water-soluble silver(I)-carbene complexes were found to be improved over that of silver nitrate.Entities:
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Year: 2004 PMID： 14761198 DOI： 10.1021/jm030262m
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446