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Literature DB >> 14760159

Sleep. 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome.

Abstract

The pathogenesis of airway obstruction in patients with obstructive sleep apnoea/hypopnoea syndrome is reviewed. The primary defect is probably an anatomically small or collapsible pharyngeal airway, in combination with a sleep induced fall in upper airway muscle activity.

Entities: Disease Species

Mesh：

Year: 2004 PMID： 14760159 PMCID： PMC1746928 DOI： 10.1136/thorax.2003.015859

Source DB: PubMed Journal: Thorax ISSN： 0040-6376 Impact factor: 9.139

48 in total

1. Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressure in man.

Authors: R L Horner; J A Innes; K Murphy; A Guz
Journal: J Physiol Date: 1991-05 Impact factor: 5.182

2. Afferent pathway(s) for pharyngeal dilator reflex to negative pressure in man: a study using upper airway anaesthesia.

Authors: R L Horner; J A Innes; H B Holden; A Guz
Journal: J Physiol Date: 1991-05 Impact factor: 5.182

3. Thoracic traction on the trachea: mechanisms and magnitude.

Authors: W B Van de Graaff
Journal: J Appl Physiol (1985) Date: 1991-03

4. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism).

Authors: W S Mezzanotte; D J Tangel; D P White
Journal: J Clin Invest Date: 1992-05 Impact factor: 14.808

5. Influence of sleep on tensor palatini EMG and upper airway resistance in normal men.

Authors: D J Tangel; W S Mezzanotte; D P White
Journal: J Appl Physiol (1985) Date: 1991-06

6. Activity of respiratory pump and upper airway muscles during sleep onset.

Authors: C Worsnop; A Kay; R Pierce; Y Kim; J Trinder
Journal: J Appl Physiol (1985) Date: 1998-09

7. Influence of passive changes of lung volume on upper airways.

Authors: F Sériès; Y Cormier; M Desmeules
Journal: J Appl Physiol (1985) Date: 1990-05

8. Induction of upper airway occlusion in sleeping individuals with subatmospheric nasal pressure.

Authors: A R Schwartz; P L Smith; R A Wise; A R Gold; S Permutt
Journal: J Appl Physiol (1985) Date: 1988-02

9. Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea.

Authors: I C Gleadhill; A R Schwartz; N Schubert; R A Wise; S Permutt; P L Smith
Journal: Am Rev Respir Dis Date: 1991-06

10. Pharyngeal size and shape during wakefulness and sleep in patients with obstructive sleep apnoea.

Authors: R L Horner; S A Shea; J McIvor; A Guz
Journal: Q J Med Date: 1989-08

43 in total

1. Obstructive sleep apnea severity correlates with cellular and plasma oxidative stress parameters and affective symptoms.

Authors: C M R Franco; A M J Lima; L Ataíde; O G Lins; C M M Castro; A A Bezerra; M F de Oliveira; J R M Oliveira
Journal: J Mol Neurosci Date: 2012-03-09 Impact factor: 3.444

Sleep. 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome.

1. Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressure in man.

2. Afferent pathway(s) for pharyngeal dilator reflex to negative pressure in man: a study using upper airway anaesthesia.

3. Thoracic traction on the trachea: mechanisms and magnitude.

4. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism).

5. Influence of sleep on tensor palatini EMG and upper airway resistance in normal men.

6. Activity of respiratory pump and upper airway muscles during sleep onset.

7. Influence of passive changes of lung volume on upper airways.

8. Induction of upper airway occlusion in sleeping individuals with subatmospheric nasal pressure.

9. Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea.

10. Pharyngeal size and shape during wakefulness and sleep in patients with obstructive sleep apnoea.

1. Obstructive sleep apnea severity correlates with cellular and plasma oxidative stress parameters and affective symptoms.

Review 2. Upperairway myopathy is important in the pathophysiology of obstructive sleep apnea.

3. Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea.

4. Modelling the human pharyngeal airway: validation of numerical simulations using in vitro experiments.

5. Lifestyle modifications and the resolution of obstructive sleep apnea syndrome: a case report.

6. Mandibular tori size is related to obstructive sleep apnea and treatment success with an oral appliance.

7. Peculiarities of clinical profile of snoring and mild to moderate obstructive sleep apnea-hypopnea syndrome patients.

8. Computational fluid dynamics simulation of the upper airway of obstructive sleep apnea syndrome by Muller maneuver.

Review 9. Sleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms.

Review 10. Association of chronic obstructive pulmonary disease and obstructive sleep apnea consequences.