| Literature DB >> 14759726 |
Uma Ramachandran1, Alka Mital, Prasad V Bharatam, Smriti Khanna, Poduri Rama Rao, Krishnamoorthy Srinivasan, Rakesh Kumar, Harmander Pal Singh Chawla, Chaman Lal Kaul, Suryaprakash Raichur, Ranjan Chakrabarti.
Abstract
Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated.Entities:
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Year: 2004 PMID： 14759726 DOI： 10.1016/j.bmc.2003.11.027
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641