| Literature DB >> 14759600 |
Myoung Seok Ko1, Unn Hwa Lee, Sin Il Kim, Hyo Jeong Kim, Jeong Jae Park, Seung Ju Cha, Sung Bum Kim, Hebok Song, Dae Kyun Chung, In Seob Han, KyuBum Kwack, Jeong Woo Park.
Abstract
Developmentally regulated GTP-binding protein (DRG) is a new subfamily within the superfamily of GTP-binding proteins. Its expression is regulated during embryonic development. To investigate the effect of the expression of DRG2 on cell growth, we constructed a human Jurkat-T-cell line that overexpresses DRG2. Overexpression of DRG2 suppressed the growth and the aggregation of Jurkat cells but did not induce apoptotic cell death. We used cDNA microarray analysis to examine the global changes in gene expression induced by an overexpression of DRG2. DNA array analyses identified genes that may suppress cell growth at a number of levels in multiple signaling cascades in Jurkat cells and also several prosurvival genes that may protect cells from apoptosis.Entities:
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Year: 2004 PMID： 14759600 DOI： 10.1016/j.abb.2003.12.028
Source DB: PubMed Journal: Arch Biochem Biophys ISSN： 0003-9861 Impact factor: 4.013