Literature DB >> 14755736

Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob disease.

Massimo Tabaton1, Salvatore Monaco, Maria Paola Cordone, Monica Colucci, Giorgio Giaccone, Fabrizio Tagliavini, Gianluigi Zanusso.   

Abstract

Currently, definite peripheral markers for the in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) are not available. Here, we report the presence of pathological prion protein in the olfactory mucosa of a case with sporadic Creutzfeldt-Jakob disease. Prion protein immunoreactivity was detected in an olfactory biopsy performed 45 days after the disease onset, suggesting that the involvement of olfactory epithelium is an early event in sporadic Creutzfeldt-Jakob disease.

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Year:  2004        PMID： 14755736     DOI： 10.1002/ana.20038

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  21 in total

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Authors:  Gianluigi Zanusso; Salvatore Monaco; Maurizio Pocchiari; Byron Caughey
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Journal:  J Clin Microbiol       Date:  2016-02-17       Impact factor: 5.948
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