Literature DB >> 14755328

Central role of the P2Y12 receptor in platelet activation.

Robert T Dorsam1, Satya P Kunapuli.   

Abstract

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.

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Year:  2004        PMID： 14755328      PMCID： PMC324551          DOI： 10.1172/JCI20986

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


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