OBJECTIVE: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on social skill and problem solving in patients with schizophrenia. METHOD: The Wisconsin Card Sorting Test and the Maryland Assessment of Social Competence were administered at baseline, week 17, and week 29 of a multisite clinical trial. RESULTS: Despite evidence of clinical improvement with both medications, there was virtually no medication effect on either social competence or problem solving. CONCLUSIONS: These findings underscore the circumscribed nature of symptomatic improvement in the broader spectrum of clinical outcomes and suggest that new-generation medications may not be expected to produce substantial changes in social role functioning or social problem-solving capacity in the community. The generalizability of the findings should be viewed cautiously because of the low power of this trial, and replication is warranted.
RCT Entities:
OBJECTIVE: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on social skill and problem solving in patients with schizophrenia. METHOD: The Wisconsin Card Sorting Test and the Maryland Assessment of Social Competence were administered at baseline, week 17, and week 29 of a multisite clinical trial. RESULTS: Despite evidence of clinical improvement with both medications, there was virtually no medication effect on either social competence or problem solving. CONCLUSIONS: These findings underscore the circumscribed nature of symptomatic improvement in the broader spectrum of clinical outcomes and suggest that new-generation medications may not be expected to produce substantial changes in social role functioning or social problem-solving capacity in the community. The generalizability of the findings should be viewed cautiously because of the low power of this trial, and replication is warranted.
Authors: S J McInerney; S Finnerty; E Walsh; L Spelman; N E Edgar; B Hallahan; C McDonald Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2018-04-28 Impact factor: 4.328
Authors: Janita Bralten; Nina R Mota; Barbara Franke; Geert Poelmans; Cornelius J H M Klemann; Ward De Witte; Emma Laing; David A Collier; Hilde de Kluiver; Stephanie E E C Bauduin; Celso Arango; Jose L Ayuso-Mateos; Chiara Fabbri; Martien J Kas; Nic van der Wee; Brenda W J H Penninx; Alessandro Serretti Journal: Neuropsychopharmacology Date: 2021-05-30 Impact factor: 7.853