Literature DB >> 14754440

Metal complexes as chemotherapeutic agents against tropical diseases: trypanosomiasis, malaria and leishmaniasis.

Roberto A Sánchez-Delgado1, Atilio Anzellotti.   

Abstract

Parasitic diseases represent a major world health problem with very limited therapeutic options, most of the available treatments being decades old and suffering from limited efficacy and/or undesirable collateral effects. The use of metal complexes as chemotherapeutic agents against these ailments appears as a very attractive alternative. Although the design of metal complexes with good therapeutic index is still rather empirical, a number of potential metal-based antiparasitic drugs have become available. In this review, advances in the use of metal complexes for the treatment of trypanosomiasis, malaria, and leishmaniasis as important representatives of the general area of tropical diseases is described.

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Year:  2004        PMID： 14754440     DOI： 10.2174/1389557043487493

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  20 in total

1.  New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.

Authors:  Bruno Demoro; Cynthia Sarniguet; Roberto Sánchez-Delgado; Miriam Rossi; Daniel Liebowitz; Francesco Caruso; Claudio Olea-Azar; Virtudes Moreno; Andrea Medeiros; Marcelo A Comini; Lucía Otero; Dinorah Gambino
Journal:  Dalton Trans       Date:  2011-12-02       Impact factor: 4.390

2.  Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase.

Authors:  Marisol Vieites; Pablo Smircich; Beatriz Parajón-Costa; Jorge Rodríguez; Verónica Galaz; Claudio Olea-Azar; Lucía Otero; Gabriela Aguirre; Hugo Cerecetto; Mercedes González; Alicia Gómez-Barrio; Beatriz Garat; Dinorah Gambino
Journal:  J Biol Inorg Chem       Date:  2008-03-06       Impact factor: 3.358

3.  Spectroscopic Study of the Interactions of Ruthenium-Ketoconazole Complexes of Known Antiparasitic Activity with Human Serum Albumin and Apotransferrin.

Authors:  Jesús G Estrada; Roberto A Sánchez-Delgado
Journal:  J Mex Chem Soc       Date:  2013       Impact factor: 0.524

4.  Metal-drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells.

Authors:  Eva Iniguez; Antonio Sánchez; Miguel A Vasquez; Alberto Martínez; Joanna Olivas; Aaron Sattler; Roberto A Sánchez-Delgado; Rosa A Maldonado
Journal:  J Biol Inorg Chem       Date:  2013-07-24       Impact factor: 3.358

5.  Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands.

Authors:  Timothy J Hubin; Prince N-A Amoyaw; Kimberly D Roewe; Natalie C Simpson; Randall D Maples; TaRynn N Carder Freeman; Amy N Cain; Justin G Le; Stephen J Archibald; Shabana I Khan; Babu L Tekwani; M O Faruk Khan
Journal:  Bioorg Med Chem       Date:  2014-05-11       Impact factor: 3.641

6.  Searching for new chemotherapies for tropical diseases: ruthenium-clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma cruzi and low toxicity toward normal mammalian cells.

Authors:  Alberto Martínez; Teresia Carreon; Eva Iniguez; Atilio Anzellotti; Antonio Sánchez; Marina Tyan; Aaron Sattler; Linda Herrera; Rosa A Maldonado; Roberto A Sánchez-Delgado
Journal:  J Med Chem       Date:  2012-04-09       Impact factor: 7.446

7.  Zinc(II)-Dipicolylamine Coordination Complexes as Targeting and Chemotherapeutic Agents for Leishmania major.

Authors:  Douglas R Rice; Paola Vacchina; Brianna Norris-Mullins; Miguel A Morales; Bradley D Smith
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

Review 8.  Advances in Chagas disease drug development: 2009-2010.

Authors:  Frederick S Buckner; Nazlee Navabi
Journal:  Curr Opin Infect Dis       Date:  2010-12       Impact factor: 4.915

9.  Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and Sporothrix spp.

Authors:  Jose Aleixo de Azevedo-França; Renato Granado; Sara Teixeira de Macedo Silva; Gabrielle Dos Santos-Silva; Sandra Scapin; Luana P Borba-Santos; Sonia Rozental; Wanderley de Souza; Érica S Martins-Duarte; Emile Barrias; Juliany Cola Fernandes Rodrigues; Maribel Navarro
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

10.  Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine.

Authors:  Chandima S K Rajapakse; Alberto Martínez; Becky Naoulou; Andrzej A Jarzecki; Liliana Suárez; Christiane Deregnaucourt; Véronique Sinou; Joseph Schrével; Elgilda Musi; Grazia Ambrosini; Gary K Schwartz; Roberto A Sánchez-Delgado
Journal:  Inorg Chem       Date:  2009-02-02       Impact factor: 5.165
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