| Literature DB >> 14751598 |
Maria Luisa Sotgiu1, Paola Bellomi, Gabriele E M Biella.
Abstract
Nociceptin (NC), administered microiontophoretically at different concentrations, significantly reduced the spontaneous and stimulus-evoked activity on WDR neuron in rats with chronic constriction of one sciatic nerve and showing signs of neuropathic pain. The effect was not antagonized by Naloxone. The same concentrations of NC were ineffective on the noxious stimulus evoked responses of WDR neurons in sham and intact rats. This result indicates a facilitated inhibitory action of NC on nociceptive transmission in this pain model.Entities:
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Year: 2004 PMID： 14751598 DOI： 10.1016/j.brainres.2003.11.025
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252