| Literature DB >> 14751549 |
Sally A McFadden1, Marc H C Howlett, James R Mertz.
Abstract
A growing eye becomes myopic after form deprivation (FD) or compensates for the power and sign of imposed spectacle lenses. A possible mediator of the underlying growth changes is all-trans retinoic acid (RA). Eye elongation and refractive error (RE) was manipulated by raising guinea pigs with FD, or a spectacle lens worn on one eye. We found retinal-RA increased in myopic eyes with accelerated elongation and was lower in eyes with inhibited elongation. RA levels in the choroid/sclera combined mirrored these directional changes. Feeding RA (25 mg/kg) repeatedly to guinea pigs, also resulted in rapid eye elongation (up to 5 times normal), and yet the RE was not effected. In conclusion, RA may act as a signal for the direction of ocular growth.Entities:
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Year: 2004 PMID： 14751549 DOI： 10.1016/j.visres.2003.11.002
Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886