Literature DB >> 14751314

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Angela Rao1, Jan Balzarini, Anna Carbone, Alba Chimirri, Erik De Clercq, Anna Maria Monforte, Pietro Monforte, Christophe Pannecouque, Maria Zappalà.   

Abstract

Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

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Year:  2004        PMID： 14751314     DOI： 10.1016/j.farmac.2003.09.001

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  3 in total

1.  An experimental and mechanism study on the regioselective click reaction toward the synthesis of thiazolidinone-triazole.

Authors:  Mahdieh Darroudi; Mahshid Hamzehloueian; Yaghoub Sarrafi
Journal:  Heliyon       Date:  2021-02-02

2.  (2E)-4-(4-Bromo-phen-yl)-2-{(2Z)-[1-(4-methyl-phen-yl)ethyl-idene]hydrazinyl-idene}-3-phenyl-2,3-di-hydro-1,3-thia-zole.

Authors:  Shaaban K Mohamed; Mehmet Akkurt; Joel T Mague; Alaa A Hassan; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-09-18

3.  Synthesis and anti-HIV studies of 2- and 3-adamantyl-substituted thiazolidin-4-ones.

Authors:  Jan Balzarini; Barbara Orzeszko-Krzesińska; Jan K Maurin; Andrzej Orzeszko
Journal:  Eur J Med Chem       Date:  2008-03-10       Impact factor: 6.514
  3 in total

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