OBJECTIVE: This study was undertaken to determine the value of a neonatal encephalopathy score (ES) and the presence of seizures for predicting 30-month neurodevelopmental outcome. STUDY DESIGN: In a cohort study, 68 term newborn infants with encephalopathy were evaluated with an ES based on alertness, feeding, tone, respiratory status, reflexes, and seizure activity (range: 0-6). Seizures were noted as present or absent clinically. Significant cognitive deficits (Mental Development Index <70), motor disability (spastic triplegia/quadriplegia), or death were abnormal outcomes. RESULTS: Twenty-two newborn infants (32%) had abnormal outcomes. With the use of maximum ES and presence of seizures from days 1 to 3 of life, 87% of newborn infants were correctly classified (area under receiver operating curve 0.93). By using ES and presence of seizures on day 1 only, 87% of newborn infants were correctly classified (area under receiver operating curve 0.89). CONCLUSION: The severity of neonatal encephalopathy and the presence of seizures are valuable predictors of 30-month neurodevelopmental outcome, as early as the first day of life.
OBJECTIVE: This study was undertaken to determine the value of a neonatal encephalopathy score (ES) and the presence of seizures for predicting 30-month neurodevelopmental outcome. STUDY DESIGN: In a cohort study, 68 term newborn infants with encephalopathy were evaluated with an ES based on alertness, feeding, tone, respiratory status, reflexes, and seizure activity (range: 0-6). Seizures were noted as present or absent clinically. Significant cognitive deficits (Mental Development Index <70), motor disability (spastic triplegia/quadriplegia), or death were abnormal outcomes. RESULTS: Twenty-two newborn infants (32%) had abnormal outcomes. With the use of maximum ES and presence of seizures from days 1 to 3 of life, 87% of newborn infants were correctly classified (area under receiver operating curve 0.93). By using ES and presence of seizures on day 1 only, 87% of newborn infants were correctly classified (area under receiver operating curve 0.89). CONCLUSION: The severity of neonatal encephalopathy and the presence of seizures are valuable predictors of 30-month neurodevelopmental outcome, as early as the first day of life.
Authors: Emily W Y Tam; Laurel A Haeusslein; Sonia L Bonifacio; Hannah C Glass; Elizabeth E Rogers; Rita J Jeremy; A James Barkovich; Donna M Ferriero Journal: J Pediatr Date: 2012-02-04 Impact factor: 4.406
Authors: S L Bonifacio; A Saporta; H C Glass; P Lee; D V Glidden; D M Ferriero; A J Barkovich; D Xu Journal: AJNR Am J Neuroradiol Date: 2012-05-17 Impact factor: 3.825
Authors: Kyle J Steinman; Maria Luisa Gorno-Tempini; David V Glidden; Joel H Kramer; Steven P Miller; A James Barkovich; Donna M Ferriero Journal: Pediatrics Date: 2009-03 Impact factor: 7.124
Authors: Hannah C Glass; Kendall B Nash; Sonia L Bonifacio; A James Barkovich; Donna M Ferriero; Joseph E Sullivan; Maria Roberta Cilio Journal: J Pediatr Date: 2011-08-11 Impact factor: 4.406
Authors: Mary J Harbert; Emily W Y Tam; Hannah C Glass; Sonia L Bonifacio; Laurel A Haeusslein; A James Barkovich; Rita J Jeremy; Elizabeth E Rogers; David V Glidden; Donna M Ferriero Journal: J Child Neurol Date: 2011-06-23 Impact factor: 1.987
Authors: Seetha Shankaran; Abbot R Laptook; Jon E Tyson; Richard A Ehrenkranz; Carla M Bann; Abhik Das; Rosemary D Higgins; Rebecca Bara; Athina Pappas; Scott A McDonald; Ronald N Goldberg; Michele C Walsh Journal: J Pediatr Date: 2011-11-01 Impact factor: 4.406