Michael P Hopkins1, George W Morley. 1. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. mhopkins@aultman.com
Abstract
OBJECTIVE: Glassy cell carcinoma of the cervix is a rare variant of cervical cancer accounting for a small percentage of cell types. This study was undertaken to review our experience with glassy cell adenocarcinoma. STUDY DESIGN: Review of adenocarcinomas from the period 1970 to 1985 was undertaken. Pathology review and survival analysis was performed comparing the glassy cell adenocarcinomas with other adenocarcinoma cell types. RESULTS: Twenty-one patients with glassy cell adenocarcinoma were identified. The mean age was 44 years. The stage distribution showed stage I=10, stage II=8, stage III=1, and stage IV=2. The cumulative survival according to stage was stage I=50%, stage II=36%, stage III=0%, and stage IV=0%. A separate analysis was performed for stage I comparing glassy cell carcinoma with other stage I adenocarcinoma cell types. The survival for stage I nonglassy cell adenocarcinoma was 61% compared with glassy cell adenocarcinoma 48% (n=10) (P=.5). A separate subset for adenosquamous carcinoma alone was performed. The survival for stage I adenosquamous carcinoma (n=30) was 58%. The survival for adenosquamous glassy cell (n=5) was 30% (P=.45). CONCLUSION: Glassy cell adenocarcinoma is a small subset of adenocarcinoma. When compared with other adenocarcinomas, survival is not significantly decreased.
OBJECTIVE:Glassy cell carcinoma of the cervix is a rare variant of cervical cancer accounting for a small percentage of cell types. This study was undertaken to review our experience with glassy cell adenocarcinoma. STUDY DESIGN: Review of adenocarcinomas from the period 1970 to 1985 was undertaken. Pathology review and survival analysis was performed comparing the glassy cell adenocarcinomas with other adenocarcinoma cell types. RESULTS: Twenty-one patients with glassy cell adenocarcinoma were identified. The mean age was 44 years. The stage distribution showed stage I=10, stage II=8, stage III=1, and stage IV=2. The cumulative survival according to stage was stage I=50%, stage II=36%, stage III=0%, and stage IV=0%. A separate analysis was performed for stage I comparing glassy cell carcinoma with other stage I adenocarcinoma cell types. The survival for stage I nonglassy cell adenocarcinoma was 61% compared with glassy cell adenocarcinoma 48% (n=10) (P=.5). A separate subset for adenosquamous carcinoma alone was performed. The survival for stage I adenosquamous carcinoma (n=30) was 58%. The survival for adenosquamous glassy cell (n=5) was 30% (P=.45). CONCLUSION:Glassy cell adenocarcinoma is a small subset of adenocarcinoma. When compared with other adenocarcinomas, survival is not significantly decreased.
Authors: Erin A Blake; Malcolm S Ross; Megan E Ross; Koji Matsuo; Emily T Silverstein; Lilibeth R Torno; Rohit Bhargava; Miriam D Post; Diane M Da Silva; Sarah Taylor; Saloni Walia; Lynda Roman; Troy A McEachron Journal: Arch Gynecol Obstet Date: 2021-08-15 Impact factor: 2.344