BACKGROUND: Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins. METHODS:Thirty-five children with > or =40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed. RESULTS:Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as alpha 1-acid glycoprotein, C3 complement, alpha 2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels. CONCLUSION: Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.
RCT Entities:
BACKGROUND: Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins. METHODS: Thirty-five children with > or =40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed. RESULTS: Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as alpha 1-acid glycoprotein, C3 complement, alpha 2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels. CONCLUSION: Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.
Authors: Rene Przkora; Marc G Jeschke; Robert E Barrow; Oscar E Suman; Walter J Meyer; Celeste C Finnerty; Arthur P Sanford; Jong Lee; David L Chinkes; Ronald P Mlcak; David N Herndon Journal: Ann Surg Date: 2005-09 Impact factor: 12.969
Authors: Demidmaa Tuvdendorj; David L Chinkes; Xiao-Jun Zhang; Oscar E Suman; Asle Aarsland; Arny Ferrando; Gabriela A Kulp; Marc G Jeschke; Robert R Wolfe; David N Herndon Journal: Surgery Date: 2011-02-18 Impact factor: 3.982
Authors: Marc G Jeschke; Celeste C Finnerty; Oscar E Suman; Gabriela Kulp; Ronald P Mlcak; David N Herndon Journal: Ann Surg Date: 2007-09 Impact factor: 12.969
Authors: Matthew W Linakis; Joseph E Rower; Susan Sorenson; Christopher A Reilly; Linda M Lambert; Richard V Williams; Phillip T Burch Journal: J Pediatr Pharmacol Ther Date: 2020
Authors: Tam N Pham; Matthew B Klein; Nicole S Gibran; Brett D Arnoldo; Richard L Gamelli; Geoffrey M Silver; Marc G Jeschke; Celeste C Finnerty; Ronald G Tompkins; David N Herndon Journal: J Burn Care Res Date: 2008 Nov-Dec Impact factor: 1.845