| Literature DB >> 14747064 |
Masataka Uehara1, Kazuo Sano, Hisazumi Ikeda, Joji Sekine, Akihiko Irie, Tomohisa Yokota, Takayoshi Tobita, Seigo Ohba, Tsugio Inokuchi.
Abstract
The correlation between expression of vascular endothelial growth factor (VEGF) and prognosis for oral squamous cell carcinoma was investigated. Tissue samples of oral squamous cell carcinoma were obtained from 63 patients. Of these patients, 11 had stage I, 17 had stage II, 9 had stage III, and 26 had stage IV tumours. Immunohistochemical expression of VEGF was quantitatively determined by computer-assisted image analysis. The value of VEGF expression was significantly higher for the patients with poor prognosis than for those with good prognosis (P=0.0423). Regarding regional lymph node metastasis, VEGF showed no significant difference between metastasis positive and negative patients. Expression of VEGF may thus be a prognostic marker for oral squamous cell carcinoma.Entities:
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Year: 2004 PMID： 14747064 DOI： 10.1016/j.oraloncology.2003.08.020
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337