OBJECTIVE: The aim of this study was to test for the presence of the fragile X (FRAXA) premutation a group of women with early menopause. STUDY DESIGN: 45 women with idiopathic premature ovarian failure (POF), five with a familial and 40 with a sporadic form, were screened for the presence of FRAXA premutation. A control group of 28 women >45 years, with one or more children and no signs of POF, was also studied. RESULTS: We found three cases of fragile X premutations in women all belonging to the group with sporadic POF. CONCLUSION: Our results seems to confirm previous observations on the non random association between POF and FRAXA premutation.
OBJECTIVE: The aim of this study was to test for the presence of the fragile X (FRAXA) premutation a group of women with early menopause. STUDY DESIGN: 45 women with idiopathic premature ovarian failure (POF), five with a familial and 40 with a sporadic form, were screened for the presence of FRAXA premutation. A control group of 28 women >45 years, with one or more children and no signs of POF, was also studied. RESULTS: We found three cases of fragile X premutations in women all belonging to the group with sporadic POF. CONCLUSION: Our results seems to confirm previous observations on the non random association between POF and FRAXA premutation.
Authors: Jennie K Kline; Ann M Kinney; Bruce Levin; Stephen A Brown; Andrew G Hadd; Dorothy Warburton Journal: Menopause Date: 2014-07 Impact factor: 2.953