| Literature DB >> 14746904 |
Alireza P- Shabanzadeh1, Ashfaq Shuaib, Tao Yang, Abdul Salam, Chen Xu Wang.
Abstract
Zinc is prevalent in the mammalian central nervous system and its role in ischemic brain injury is still controversial. In the present study, the effect of zinc in ischemic brain injury was examined in an embolic model of stroke in rats. Furthermore, the effect of zinc in combination with bicuculline, a GABAa antagonist, was also examined in the ischemic injury. Treatment with zinc or zinc plus bicuculline increased infarct volume significantly and also worsened neurological deficits. Moreover, treatment with zinc plus bicuculline also enhanced ischemic brain edema. These results thus support the hypothesis that administration of zinc i.p. worsens the outcome of ischemic brain injury in the embolic model of stroke in rats.Entities:
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Year: 2004 PMID： 14746904 DOI： 10.1016/j.neulet.2003.10.073
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046