| Literature DB >> 14746891 |
Emi Kumamaru1, Che-Hui Kuo, Takahiro Fujimoto, Keiko Kohama, Ling-Hui Zeng, Eiichi Taira, Hidekazu Tanaka, Tetsuya Toyoda, Naomasa Miki.
Abstract
Reticulon3 (RTN3), which belongs to a reticulon family, is first isolated from the retina, but little is known about its function. We investigated the distribution of RTN3 in rat retina and olfactory bulb by immunohistochemistry. In the retina, Müller cells highly expressed RTN3. The expression level of RTN3 in the optic nerve was high in the embryo, but low in the adult. In the olfactory system, RTN3 was highly expressed in the olfactory nerve both in developmental and adult stages. Further, RTN3 was co-localized with synaptophysin in tubulovesicular structures in the developing axon of cultured cortical neurons. These results suggest that RTN3 may play an important role in the developing axons and also in some glial cells such as Müller cells.Entities:
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Year: 2004 PMID： 14746891 DOI： 10.1016/j.neulet.2003.11.009
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046