Literature DB >> 14746876

Microglia-derived glial cell line-derived neurotrophic factor could protect Sprague-Dawley rat astrocyte from in vitro ischemia-induced damage.

Gilbert A Lee1, Chi-Hsin Lin, Hang-Hsiang Jiang, Hsin-Ju Chao, Chieh-Liang Wu, Chi-Mei Hsueh.   

Abstract

The interrelationship between microglia and astrocytes in cerebral ischemia was determined in vitro by adding in vitro ischemia-induced supernatant from microglia into astrocytes under the same conditions (glucose-, oxygen- and serum-free). The involvement of glial cell line-derived neurotrophic factor (GDNF) was further investigated by immunoblocking assay and Western blot analysis. Results showed that microglia-derived supernatant protected against in vitro ischemia-induced damage of astrocytes and this protection was pre-blocked by anti-GDNF but not normal rabbit serum. In addition, in vitro ischemia appeared to induce the expression of GDNF in microglia. These results indicate that microglia-derived protection on astrocytes during in vitro ischemia is GDNF-dependent.

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Year:  2004        PMID： 14746876     DOI： 10.1016/j.neulet.2003.11.030

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

1.  Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke.

Authors:  Chi-Hsin Lin; Li-Ya Liao; Tsung-Ying Yang; Yi-Jyun Chang; Chia-Wen Tung; Shih-Lan Hsu; Chi-Mei Hsueh
Journal:  Cell Mol Neurobiol       Date:  2019-03-09       Impact factor: 5.046

2.  Hydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice.

Authors:  P K Kamat; A Kalani; S Givvimani; P B Sathnur; S C Tyagi; N Tyagi
Journal:  Neuroscience       Date:  2013-07-31       Impact factor: 3.590

3.  Changes in transcript and protein levels of calbindin D28k, calretinin and parvalbumin, and numbers of neuronal populations expressing these proteins in an ischemia model of rat retina.

Authors:  Shin Ae Kim; Ji Hyun Jeon; Min Jeong Son; Jiook Cha; Myung-Hoon Chun; In-Beom Kim
Journal:  Anat Cell Biol       Date:  2010-09-30

Review 4.  Understanding the Connection Between Common Stroke Comorbidities, Their Associated Inflammation, and the Course of the Cerebral Ischemia/Reperfusion Cascade.

Authors:  Łukasz Przykaza
Journal:  Front Immunol       Date:  2021-11-15       Impact factor: 7.561

Review 5.  Glial Cell Line-Derived Neurotrophic Factor Family Ligands, Players at the Interface of Neuroinflammation and Neuroprotection: Focus Onto the Glia.

Authors:  Anastasiia Kotliarova; Yulia A Sidorova
Journal:  Front Cell Neurosci       Date:  2021-06-17       Impact factor: 5.505

6.  Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia.

Authors:  Jianping Wang; Zhitang Yang; Cong Liu; Yuanzheng Zhao; Yibing Chen
Journal:  Int J Mol Med       Date:  2012-11-13       Impact factor: 4.101

Review 7.  The Role of Activated Microglia and Resident Macrophages in the Neurovascular Unit during Cerebral Ischemia: Is the Jury Still Out?

Authors:  Rawan Barakat; Zoran Redzic
Journal:  Med Princ Pract       Date:  2015-08-19       Impact factor: 1.927
  7 in total

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