| Literature DB >> 14746347 |
Masaaki Kurata1, Yukiko Sasayama, Naoko Yamasaki, Ikue Kitazawa, Yoshimasa Hamada, Ikuo Horii.
Abstract
The possible mechanisms for shortening prothrombin time (PT) and activated partial thromboplastin time (APTT) were investigated using citrated plasma from rats and dogs in vitro, especially focusing on increased fibrinogen concentrations. When purified canine fibrinogen was added to citrated canine plasma at final concentrations of 2, 4 and 8 mg/mL, PT and APTT were significantly shortened. The increased concentrations of clottable fibrinogen in the test system were confirmed by markedly shortened thrombin time (TT). In citrated rat plasma, while purified rat fibrinogen had no effect on PT or APTT at final concentrations of 2, 4 and 8 mg/mL, it did shorten TT. These results suggest that an increased concentration of fibrinogen is a possible mechanism to shorten PT and APTT in dogs, but not in rats.Entities:
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Year: 2003 PMID： 14746347 DOI： 10.2131/jts.28.439
Source DB: PubMed Journal: J Toxicol Sci ISSN： 0388-1350 Impact factor: 2.196