Literature DB >> 14745685

[Is premature termination of opiate detoxification due to intensive withdrawal or craving?].

N Scherbaum1, K Heppekausen, F Rist.   

Abstract

Opiate addicts terminate inpatient detoxification prematurely in about 50% of treatment episodes. Premature termination of treatment is often considered to be motivated by intensive withdrawal symptoms. Therefore, the relation between discontinuing treatment and the intensity of withdrawal symptoms and heroin craving is investigated. 130 opiate addicts consecutively admitted to a detoxification ward daily assessed the intensity of withdrawal symptoms on the Short Opiate Withdrawal Scale (SOWS) as well as the intensity of heroin craving on a visual analogue scale. Withdrawal symptoms were treated by stepwise reduction of methadone and symptom-oriented medication. 66 patients (50.8%) terminated treatment prematurely. However, during the days preceding treatment termination, these patients did not differ from regularly detoxified patients assessed on corresponding days with respect to craving, and reported even less intensity of withdrawal symptoms. In conclusion, neither the intensity of withdrawal symptoms nor the intensity of heroin craving constitutes the primary reason for premature termination of detoxification.

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Year:  2004        PMID: 14745685     DOI: 10.1055/s-2003-812451

Source DB:  PubMed          Journal:  Fortschr Neurol Psychiatr        ISSN: 0720-4299            Impact factor:   0.752


  5 in total

1.  Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence.

Authors:  Douglas M Ziedonis; Leslie Amass; Marc Steinberg; George Woody; Jonathan Krejci; Jeffrey J Annon; Allan J Cohen; Nancy Waite-O'Brien; Susan M Stine; Dennis McCarty; Malcolm S Reid; Lawrence S Brown; Robert Maslansky; Theresa Winhusen; Dean Babcock; Greg Brigham; Joan Muir; Deborah Orr; Betty J Buchan; Terry Horton; Walter Ling
Journal:  Drug Alcohol Depend       Date:  2008-09-20       Impact factor: 4.492

2.  [Neurobiology of opioid dependence].

Authors:  N Scherbaum; U Bonnet
Journal:  Anaesthesist       Date:  2019-03       Impact factor: 1.041

3.  [Neurobiology of opioid dependence].

Authors:  N Scherbaum; U Bonnet
Journal:  Schmerz       Date:  2018-12       Impact factor: 1.107

4.  Predictors of attrition with buprenorphine/naloxone treatment in opioid dependent youth.

Authors:  Diane Warden; Geetha A Subramaniam; Thomas Carmody; George E Woody; Abu Minhajuddin; Sabrina A Poole; Jennifer Potter; Marc Fishman; Michael Bogenschutz; Ashwin Patkar; Madhukar H Trivedi
Journal:  Addict Behav       Date:  2012-05-08       Impact factor: 3.913

5.  Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: a discrete survival and growth mixture model.

Authors:  Thomas F Northrup; Angela L Stotts; Charles Green; Jennifer S Potter; Elise N Marino; Robrina Walker; Roger D Weiss; Madhukar Trivedi
Journal:  Addict Behav       Date:  2014-09-28       Impact factor: 3.913

  5 in total

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